Senior Scientist, Drug Metabolism and Pharmacokinetics

BoehringerPRD•Brampton, ON

3d•$140,000 - $222,000•Onsite

About The Position

Boehringer Ingelheim is seeking an enthusiastic, creative and highly motivated Senior Scientist to join the Reagents and Mechanistic Investigations group in Drug Metabolism & Pharmacokinetics (DMPK) at our US headquarters in Ridgefield, CT. The main responsibility of this position is to develop cell based and competitive ligand binding assays to evaluate neutralization activity of anti-drug antibodies in clinical samples, in support of clinical immunogenicity assessments. The Senior Scientist will design and execute independent research that supports R&D projects and is primarily responsible for performing and managing scientific and technical activities, which may also include responsibility for the management of scientific staff. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies´ success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim´s high regard for our employees.

Requirements

Ph.D. Degree or equivalent experience in a related field
Demonstrates a broad knowledge of field
Appropriate level of understanding of applicable regulations
Ability to communicate effectively both orally and in writing in an inter disciplinary environment
Demonstrated expertise in developing novel in vitro cell-based and ligand binding-based immunoassays for use in regulated bioanalysis of clinical studies.
Experience with validation of bioanalytical immunoassay methods for biologics in a regulated environment (GLP/GCP) is highly desirable.
Proficiency in cell culture, cell signaling pathways, cell proliferation, apoptosis & cytotoxicity assays; experience in the generation of reporter cell lines/reporter assays is highly desirable.
Hands on experience in ELISA, multiple assay platforms (Envision, Spectramax, MSD etc), flow cytometry experience a plus.
Ability to operate laboratory equipment with independence.
Proven problem-solving ability.
Excellent oral and written communication skills.
Be a team player in a matrix environment.

Nice To Haves

Experience with validation of bioanalytical immunoassay methods for biologics in a regulated environment (GLP/GCP)
Experience in the generation of reporter cell lines/reporter assays
Flow cytometry experience

Responsibilities

Independently design, develop and perform cell based and competitive ligand binding assays to detect neutralizing antibodies against biological therapeutics; may direct and oversee experimental design and results of technicians and junior level scientists
Initiate and complete routine procedures in an independent and efficient manner; Troubleshoot effectively and solves scientific problems independently; Operate and maintain lab equipment.
Develops an understanding of R&D team goals and works effectively toward achieving them; Either assumes departmental responsibility for projects when necessary or has ability to participate as representative on multiple project teams and contribute to defining expertise-related aspects of overall program goals
Prepares clear technical reports, publications and oral presentations. Independently communicates results in the form of reports and or presentations; Presents responsibly and defends own work at meetings; May deliver updates to senior level management in context of overall project goals
Develops expertise in a specific project-relevant area or technology; May provide guidance and expertise to advance specific projects or evaluate and propose new technologies and concepts in support of multiple projects; Ability to work with various LIMS; Compilation of associated outputs with supervision
Independently apply basic scientific principles, perform literature searches, attend scientific meetings, and keep abreast of literature in relevant scientific fields.
Assumes responsibility for direct reports as needed including recruiting, managing, mentoring and developing scientific staff; serve as scientific monitor for assay performance and project management at external CROs.
Complies with all applicable regulations; Ensures that work performed in area of responsibility is conducted in a safe and compliant manner; Maintains proper records in accordance with SOPs and policies
Contributes to departmental administration; Demonstrates fiscal responsibility with respect to cost of experiments, technology, external collaborations, and travel