Senior Scientist, Drug Discovery Biochemistry & Biophysics

Integrated Biosciences, Inc.•Redwood City, CA

6h•$120,000 - $175,000•Onsite

About The Position

Integrated Bio is seeking a driven and highly skilled Senior Scientist to build and execute our protein biochemistry, biophysics, and drug discovery assay capabilities. In this onsite role, you will design, produce, and characterize high-quality recombinant proteins, develop robust biochemical and biophysical assays, and build focused cellular assay cascades that connect target engagement and mechanism to cellular pharmacology. Your work will generate decision-quality data on potency, selectivity, mechanism, kinetics, reversibility, compound artifacts, and molecular and cellular biology. You'll partner closely with the rest of our biology team along with medicinal chemistry to turn screening hits into mechanistically understood and optimizable chemical matter. This role is ideal for someone who enjoys working at the interface of protein science, biophysics, cell-based pharmacology, and small molecule drug discovery. If you're someone who loves making difficult assays work, understanding how compounds engage their targets to influence biology, and using rigorous quantitative data to move the needle on human aging, we want to hear from you.

Requirements

A PhD in biochemistry, biophysics, chemical biology, structural biology, pharmacology, cell biology, or a closely related field
3-5 years of industry experience in small molecule drug discovery, developing biochemical, biophysical, and/or cellular assays
Hands-on experience in recombinant protein expression, purification, and analytical characterization, independently generating high-quality reagents for quantitative assays
A strong grasp of assay development principles (robustness, reproducibility, dynamic range, signal-to-background, Z', CV, etc.)

Nice To Haves

Experience with structural biology methods such as NMR, X-ray crystallography, or cryo-EM
Familiarity with aging biology, senescence, mitochondrial function, proteostasis, inflammatory signaling, metabolic pathways, or other age-related disease biology
Experience leveraging AI and coding agents in the context of drug discovery, computational chemistry, and large-scale biological datasets

Responsibilities

Design, express, purify, and characterize recombinant proteins to support biochemical, biophysical, target engagement, and structural studies
Develop construct, tag, truncation, mutation, and purification strategies, and apply analytical methods (SEC, SDS-PAGE, activity, LC-MS, DLS, thermal shift, etc.) to assess protein purity, identity, oligomeric state, stability, and assay suitability
Develop, validate, and run biochemical and biophysical assays (FP, TR-FRET, AlphaScreen/AlphaLISA, DSF, enzymatic, SPR, BLI) to support hit validation, SAR, selectivity, mechanism of action, and lead optimization
Generate quantitative data on affinity, potency, kinetics, residence time, reversibility, competition, allostery, and selectivity, and design orthogonal assays
Partner with medicinal chemistry to interpret SAR, prioritize compounds, and shape assay strategy
Build focused cell-based assays that connect biochemical and biophysical target engagement to cellular pharmacology, covering target engagement, pathway modulation, biomarker response, potency, selectivity, and counterscreens
Develop fit-for-purpose readouts (e.g. high content cell imaging, qPCR, reporter, viability) for SAR and mechanism