Senior Scientist, Downstream Process Development

Johnson & Johnson Innovative Medicine•Spring House, PA

1d•Onsite

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. We are searching for the best talent for a Senior Scientist, Downstream Process Development to be in Spring House, PA. The Senior Scientist, Downstream Process Development will lead development, optimization, and characterization of scalable purification processes for Lentiviral In-vivo therapeutic modalities, including biologics, and next-generation genetic medicines. This role will provide scientific leadership from early-stage development through clinical-stage readiness, with focus on purification platform strategy, process robustness, scale-up, and implementation of advanced downstream technologies.

Requirements

PhD in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 1-3 years of relevant industry experience; OR a BS or MS with 4-6 years of relevant experience.
Extensive experience in downstream process development for biologics, cell therapy, gene therapy, or related viral vector modalities.
Hands-on experience with chromatography, clarification, depth filtration, UF/DF, sterile filtration, and process scale-up.
Experience operating and/or leading studies using AKTA chromatography systems, TFF platforms, and Ambr® TFF systems.
Strong understanding of downstream process control strategies, process analytics, and process characterization principles.
Demonstrated ability to independently design, execute, interpret, and communicate complex studies.
Proven scientific leadership, mentoring, and project management experience.

Nice To Haves

Experience with high-throughput purification screening, Ambr® TFF workflows, and scale-down model qualification.
Familiarity with PAT tools, automation, digital bioprocessing, and advanced data analytics platforms.
Track record of scientific publications, presentations, patents, technology innovation, or cross-functional platform impact.

Responsibilities

Lead development and optimization of downstream purification processes for lentiviral in vivo LV therapeutic products.
Design and oversee chromatography, filtration, UF/DF, and formulation studies to improve product quality, yield, robustness, and manufacturability.
Utilize advanced filtration technologies, including Ambr® TFF, for high-throughput process screening, optimization, and scale-down model development.
Oversee operation and troubleshooting of downstream equipment, including AKTA systems, TFF systems, and chromatography skids.
Apply Process Analytical Technology, online monitoring, and digital bioprocessing tools to strengthen downstream process understanding.
Use JMP, MiniTab, Python, Spotfire, or similar platforms for multivariate data analysis, process modeling, and technical decision-making.
Lead process characterization, scale-up, and platform development activities to support clinical manufacturing readiness.
Evaluate emerging purification technologies and drive continuous improvement to enhance process robustness and development efficiency.
Collaborate closely with analytical, formulation, upstream, modeling, automation, MSAT, and translational sciences teams.
Mentor junior scientists and provide scientific leadership across programs and cross-functional workstreams.
Prepare technical reports, development strategies, scientific presentations, and regulatory documentation.