Senior Scientist, Downstream Process Development R&D

Pfizer • Bothell, WA

2d • Onsite

About The Position

A Senior Scientist (R4) position in the Downstream Process Development group within Bioprocess R&D. The role is part of a multidisciplinary, multi-site team developing and optimizing recovery and purification processes for recombinant proteins expressed in mammalian cell culture, supporting early- and late-phase clinical programs. The successful candidate will bring strong laboratory research experience and an interest in a hands-on, laboratory-focused role. They will collaborate on robust, efficient, and scalable downstream strategies to improve process performance and enable successful technology transfer.

Requirements

• Bachelor’s degree with 8+ years of relevant experience, Master’s degree with 6+ years of relevant experience, or PhD with 0–3 years of experience.
• Degree in a biological or engineering discipline, such as Biotechnology, Chemistry/Biochemistry, Chemical or Biochemical Engineering, or equivalent.
• Hands-on experience in recombinant protein downstream process development, technology transfer, and/or bioprocess manufacturing.
• Strong understanding of protein chemistry and protein analytics, with demonstrated ability to apply current scientific literature.
• Ability to independently drive experimental work, deliver results, and contribute innovative solutions within project teams.
• Highly organized and self-motivated, with the ability to work independently and collaboratively in a matrix environment.
• Excellent written and verbal communication skills, including technical documentation and presentations.
• Strong analytical, data interpretation, and computer skills.
• Ability to manage personal workload effectively and contribute to planning people and technology resources within project teams.
• Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and enhance productivity.
• Curiosity about how AI tools can improve outcomes and understanding of responsible AI practices, including risk management and ethical use.
• Permanent work authorization in the United States; U.S. work visa sponsorship is not available.

Nice To Haves

• Experience with recovery and purification of recombinant proteins from mammalian and microbial or yeast expression systems.
• Experience transferring biologics processes to pilot-scale or commercial manufacturing, including familiarity with data acquisition and process control systems.
• Experience supporting late-stage development, process validation, and commercialization activities.
• Working knowledge of statistical experimental design and data analysis.
• Broad understanding of the biologics drug development process and requirements for advancing candidates through clinical development.

Responsibilities

• Design and execute small-scale downstream process development studies, and support pilot-scale and manufacturing purification activities.
• Analyze experimental data to develop, test, and refine hypotheses that improve understanding of recovery and purification processes.
• Contribute to process characterization, validation strategies, Quality by Design (QbD) approaches, and regulatory filings.
• Author internally reviewed technical reports, present scientific results to cross-functional teams and management, and publish externally as appropriate.
• Identify and implement opportunities for operational efficiency and continuous improvement across Bioprocess R&D workflows.
• Support change initiatives related to business infrastructure, platforms, and technologies for pipeline, legacy, and innovation programs.

Benefits

• Eligible to participate in Pfizer’s Global Performance Plan, with a bonus target of 12.5% of base salary.
• Eligible to participate in Pfizer’s share-based long-term incentive program.
• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday, and personal days.
• Paid caregiver/parental and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior