Senior Associate Scientist, Biologics Downstream Process Development
About The Position
Asimov is seeking a Senior Associate Scientist, Biologics Downstream Process Development to help advance biopharmaceutical and gene therapy process development. The role conducts bioprocess engineering for biologics, designs experimental approaches to improve workflows and systems, applies scaling principles to upstream and downstream processing—with emphasis on downstream—and coordinates interdepartmental project efforts. The position works closely with synthetic biology, cell line development, and analytical development teams, and interfaces with external partners. It reports to the Lead Scientist for Downstream Process Development. The role includes hands-on bioreactor scale-up, harvest, downstream processing, purification, and product quality assessment, as well as cross-functional project representation, technology transfer, data-platform collaboration, and documentation.
Requirements
- Master’s degree in Biological Engineering, Chemical Engineering, Cell Biology, Molecular Biology, or a related field and at least 4 years of relevant hands-on bioprocessing experience; or a bachelor’s degree and at least 6 years of hands-on industry experience.
- Downstream purification experience optimizing Protein A (ProA) and ultrafiltration/diafiltration (UF/DF) steps.
- Experience using chromatography systems and their human-machine interface, such as ÄKTA/UNICORN.
- Experience with mammalian (CHO) and/or viral vector process development.
- Strong spreadsheet skills, such as Google Sheets or Excel.
- Experience using design-of-experiments (DOE) software to develop robust experiments.
- Creative problem-solving ability, attention to detail, strong organization, and experience following standardized workflows or pipelines.
Nice To Haves
- Experience with additional chromatography and polishing steps, such as ion-exchange chromatography (IEX) and hydrophobic interaction chromatography (HIC).
- Knowledge and experience in technology transfer of manufacturing processes and generation of GLP toxicology material.
- Experience with Spotfire, Google Apps Script (JavaScript), and/or BigQuery for data management and analysis.
Responsibilities
- Perform clarification, downstream processing and purification, and product quality assessment using analytical tools.
- Participate hands-on in projects involving bioreactor scale-up (2 L+), process development, harvest, and downstream process development.
- Serve as a technical subject matter expert in at-scale process development for internal and external projects.
- Represent the process development team on cross-functional projects, make decisions about process development activities, and communicate results, progress, and plans.
- Work with strategic alliance and commercial teams to transfer developed processes and early-look materials to external partners.
- Partner with the software team to develop integrated data platforms and analysis for streamlined data analysis.
- Author, review, and approve process development reports and technology transfer protocols.
- Organize and document experiments and data in an electronic lab notebook.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
