Senior Scientist, Downstream Process/Antibody-Drug Conjugation

Johnson & Johnson Innovative Medicine • Malvern, PA

1d • Onsite

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Requirements

• Ph.D. degree in Chemistry, Chemical Engineering, Biochemistry or related field and 3 years of experience in the job offered or in a Senior Scientist, Downstream Process/Antibody-Drug Conjugation-related occupation.

Responsibilities

• Support and serve as lead for process development of Antibody-Drug Conjugates (ADCs), Radio-Ligand Therapies (RLTs), Immune-Stimulating Antibody Conjugates (ISACs), siRNA antibody conjugates within the API-Protein group.
• Lead method and process development activities, process characterization studies, scale-up and tech transfer activities to support large scale GLP and GMP batch manufacturing.
• Lead the design and execution of development studies to identify and determine appropriate conditions and ranges of critical process parameters for bioconjugation reactions, chromatographic purification, and several types of tangential flow filtration approaches.
• Lead the design of experiments, execute planned experiments, optimize process steps to the target process scale at laboratory scale, and participate in the non-GMP and GMP pilot-scale.
• Record and analyze experimental data, verify data integrity and accuracy, and summarize and report findings.
• Author technical protocols, reports and regulatory filings.
• Participate in scoping of laboratory expansion, engage with vendors to source equipment and onboard new instrumentation for ADC lab build activities.
• Lead and guide junior scientists to execute various studies for ADC projects, ensure timely completion of deliverables, engage department and global leadership to seek project advancement endorsements, and author technical project development (PD) reports.

Benefits

• Consolidated retirement plan (pension)
• Savings plan (401(k))
• Long-term incentive program
• Vacation –120 hours per calendar year
• Sick time - 40 hours per calendar year (or 48/56 hours in CO/WA)
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year
• Medical
• Dental
• Vision

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree