Senior Scientist, Formulation Delivery Systems
About The Position
CSL is seeking a Senior Scientist, Delivery Technologies to provide scientific expertise in the design, formulation, characterization, and optimization of delivery technologies supporting drug discovery across multiple functions and external collaborations. The role focuses on lipid nanoparticle (LNP) formulation, extrahepatic targeted delivery, siRNA conjugates for tissue- and cell-specific delivery, and translational drug delivery sciences. The position is based onsite in Waltham, Massachusetts, five days per week. The successful candidate will contribute to CSL's novel modalities portfolio and pipeline, lead delivery technology research, and provide subject-matter expertise and technical support across research, development, and manufacturing activities. The role reports to the Principal Scientist, Delivery Technologies. Relocation assistance and visa sponsorship are not provided.
Requirements
- PhD with 5 or more years of relevant pharmaceutical-industry experience, or MS with 7 or more years of relevant pharmaceutical-industry experience, in Pharmaceutical Sciences, Nanomedicine, Biomedical Engineering, Chemistry, Chemical Engineering, or Drug Delivery.
- Demonstrated ability to independently lead scientific projects and experience working in cross-functional research environments.
- Strong track record in LNP formulation and optimization.
- Expertise in nanoparticle characterization, including particle size, encapsulation efficiency, and stability assessment.
- Expertise in in vitro and in vivo evaluation of RNA-based delivery systems.
- Understanding of cellular uptake mechanisms, intracellular trafficking, and endosomal escape.
- Demonstrated experience with targeted LNPs and extrahepatic delivery platforms.
- Experience with experimental design, statistical analysis, and data interpretation.
Nice To Haves
- Knowledge of medicinal chemistry principles related to ionizable lipid design, structure-activity relationships (SAR), ligand optimization, and linker chemistry.
Responsibilities
- Contribute to and support CSL’s novel modalities portfolio and pipeline.
- Participate in external due diligence, assessing delivery system suitability for different modalities, technical feasibility, and risk.
- Lead the design, formulation, and characterization of LNPs containing siRNA, mRNA, gene-editing cargoes, and other nucleic acid modalities.
- Design and execute formulation screening using Design of Experiment (DOE) principles.
- Work on medium- to high-throughput formulation preparation.
- Optimize formulation parameters, lipid composition, manufacturing processes, and excipient systems to improve stability and biological performance.
- Develop and characterize targeted delivery strategies using receptor-mediated uptake mechanisms, targeting ligands, and tissue-specific approaches.
- Lead the design and evaluation of ligand-siRNA conjugates for extrahepatic delivery.
- Evaluate delivery performance through in vitro and in vivo studies, including cellular uptake, endosomal escape, biodistribution, and target engagement.
- Serve as a subject matter expert in delivery approaches and LNP process development, and provide technical delivery-related support across research, development, and manufacturing activities.
- Apply mechanistic insights to critical process parameters and product attributes through hypothesis-driven experimentation, robust data analysis, and problem-solving.
- Provide scientific guidance and mentorship to team members and collaborate closely with Analytical Biochemistry and Molecular Biology teams.
Benefits
- Incentive compensation may be included in total compensation.
- Equity may be included in total compensation.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
