Sr Scientist - Chemical Engineer for Drug Linker

Pfizer • Bothell, WA

2d • Onsite

About The Position

Pfizer is seeking a chemical engineer to join the Drug Linker (DL) Process Development team within Chemical Process and Analytical Development (CPAD) in Bothell, Washington. The team develops Drug Linker processes for manufacturing across Pfizer’s network. CPAD, part of Pfizer R&D in Pharmaceutical Sciences, develops process technology for manufacturing Drug Linker used in Antibody Drug Conjugates, covering work from small-scale synthesis supporting medicinal chemistry programs through development and optimization of commercial manufacturing processes.

The role leads and supports engineering activities in process development, scale-up, and technology transfer to clinical and commercial manufacturing sites and external facilities. It combines engineering laboratory experiments with process modeling, statistics, and solid-state analysis. This is a laboratory-based position with opportunities for cross-training and technology development. The employee may spend time at technology-transfer sites supporting manufacturing activities.

The position is onsite in Bothell, WA. Due to global operations, the employee may need to attend teleconferences outside core Pacific Time working hours. Local business travel to support vendor oversight is less than 10% of work time. Relocation support may be available based on business needs and eligibility. Candidates must have permanent U.S. work authorization; visa sponsorship is unavailable.

Requirements

• Bachelor’s degree and at least 9 years of experience, or master’s degree and more than 7 years of experience, or PhD and 0 or more years of relevant experience.
• Expertise in reaction engineering, including experience developing and validating kinetic models from experimental data.
• Excellent knowledge of chemistry and chemical engineering principles, including chemical reactor design, thermodynamics, transport phenomena, engineering statistics, and process modeling.
• Outstanding laboratory skills, attention to detail, and ability to solve technical problems.
• Exceptional interpersonal, multidisciplinary collaboration, and communication skills.

Nice To Haves

• Experience transferring processes to external manufacturing partners.
• Experience with Process Analytical Technologies (PAT), such as Raman, FTIR, NIR, online HPLC, and FBRM.
• Experience with separation processes such as Tangential Flow Filtration (TFF), membrane separation, chromatography purification, or Supercritical Fluid Precipitation/Extraction.
• Foundational understanding of organic chemistry.
• Experience building reaction or unit-operation models using software such as DynoChem, Reaction Lab, ASPEN, gPROMS, VisiMix, COSMOtherm, or MATLAB.
• Knowledge and experience applying Design of Experiments.
• Strong organizational, time-management, and problem-solving skills.
• Team-oriented approach, good communication skills, and motivation to achieve team and individual goals.
• Strong technical writing and presentation skills.
• Working knowledge of analytical techniques such as HPLC/UPLC, MS, PXRD, DSC, TGA, and NMR.
• Experience applying data science methods such as machine learning and AI.

Responsibilities

• Apply engineering knowledge to develop safe, sustainable, robust, scalable, cost-efficient, and phase-appropriate processes aligned with internal business needs.
• Prepare internal research reports and technical presentations documenting process development and conveying process understanding to manufacturing partners.
• Lead or support purification and isolation process development for internal pre-clinical materials supply.
• Independently design, implement, and interpret data-rich experiments.
• Design experiments to evaluate manufacturing process scalability and support successful technology transfer.
• Apply knowledge of unit-operation design, process modeling and optimization, equipment selection, and scale-up methodologies.
• Use process modeling approaches to support robust technology transfer to pilot and commercial-scale facilities.
• Assist with technology transfer to internal or external clinical and commercial manufacturing sites and partners, including possible onsite support of manufacturing activities.
• Collaborate with process chemists and analytical chemists on synthetic strategy and route development.
• Develop and implement technologies to improve processes at external manufacturing partners.
• Maintain knowledge of laboratory data management systems and use suitable modeling tools to derive process understanding from data-rich experiments.
• Stay current with process engineering and chemistry literature; potentially author external publications and present research at conferences.
• Contribute to a safe, inclusive, and innovative culture in engineering and chemistry laboratories.
• Collaborate effectively and build and lead high-performing teams.
• Document experimental work accurately and promptly, and communicate results clearly to internal and external stakeholders.
• Identify opportunities to align, share, and implement best practices across sites.

Benefits

• 401(k) plan with Pfizer matching contributions and an additional Pfizer Retirement Savings Contribution
• Paid vacation, holidays, and personal days
• Paid caregiver, parental, and medical leave
• Medical, prescription drug, dental, and vision coverage
• Eligibility to participate in Pfizer’s Global Performance Plan, with a bonus target of 12.5% of base salary
• Eligibility to participate in a share-based long-term incentive program
• Relocation assistance may be available based on business needs and eligibility

What This Job Offers

• Job Type: Full-time
• Career Level: Senior