Sr Scientist - Chemical Engineer for Drug Linker

Pfizer • Bothell, WA

3d • $93,600 - $156,000 • Onsite

About The Position

Pfizer is seeking a chemical engineer to join its Drug Linker (DL) Process Development team within Chemical Process and Analytical Development (CPAD) in Bothell, Washington. The team develops Drug Linker processes for manufacturing sites across Pfizer’s network. The role applies chemical engineering principles to develop, optimize, and scale up DL manufacturing processes, using laboratory experimentation, process modeling, statistics, and solid-state analysis.

CPAD, part of Pfizer R&D in Pharmaceutical Sciences, develops process technology to manufacture Drug Linker for Antibody Drug Conjugates. Working with chemists and analysts, the Senior Scientist will lead engineering activities across process development, scale-up, and technology transfer to clinical and commercial manufacturing sites and external facilities. This laboratory-based role offers cross-training and opportunities to develop new technologies. The work includes collaboration in a dynamic team environment with fast-paced project timelines.

The position is based on premise. Supporting global operations may require attending teleconference meetings outside core Pacific Time work hours. Local business travel for vendor oversight may account for less than 10% of work time. Relocation support may be available based on business needs and eligibility. The annual base salary range is $93,600 to $156,000, with eligibility for Pfizer’s Global Performance Plan (12.5% target bonus) and share-based long-term incentives.

Requirements

• Bachelor’s degree and at least 9 years of experience, or master’s degree and more than 7 years of experience, or Ph.D. and at least 0 years of relevant experience.
• Expertise in reaction engineering, including experience developing and validating kinetic models from experimental data.
• Excellent knowledge of chemistry and chemical engineering principles, and a sound understanding of chemical reactor design, thermodynamics, transport phenomena, engineering statistics, and process modeling.
• Outstanding laboratory skills, attention to detail, and ability to solve technical problems.
• Exceptional interpersonal, multidisciplinary collaboration, and communication skills.
• Authorization to be employed in the United States by any employer; U.S. work visa sponsorship is not available.

Nice To Haves

• Experience transferring processes to external manufacturing partners.
• Experience with Process Analytical Technologies (PAT), such as Raman, FTIR, NIR, online HPLC, and FBRM.
• Experience with separation processes such as Tangential Flow Filtration (TFF), membrane separation, chromatography purification, or Supercritical Fluid Precipitation/Extraction.
• Foundational understanding of organic chemistry.
• Experience building reaction or unit-operation models using software such as DynoChem, Reaction Lab, ASPEN, gPROMS, VisiMix, COSMOtherm, or MatLab.
• Knowledge and experience applying Design of Experiments.
• Strong organization, time-management, and problem-solving skills.
• Team-oriented approach and good communication skills, with a desire to achieve team and individual goals.
• Strong technical writing and presentation skills.
• Working knowledge of analytical techniques such as HPLC/UPLC, MS, PXRD, DSC, TGA, and NMR.
• Applied data science methods, such as machine learning and AI.

Responsibilities

• Apply engineering knowledge to develop safe, sustainable, robust, scalable, cost-efficient, and phase-appropriate processes aligned with internal business needs.
• Prepare internal research reports and technical presentations that summarize process development and transfer process knowledge to manufacturing partners.
• Lead or support purification and isolation process development for internal pre-clinical materials supply.
• Independently design, implement, and interpret data-rich experiments.
• Design experiments to assess manufacturing process scalability and support successful technology transfer.
• Apply unit-operation design, process modeling and optimization, process equipment selection, and scale-up methodologies.
• Use process modeling approaches to support robust technology transfer to pilot and commercial-scale facilities.
• Assist with technology transfer to internal or external clinical and commercial manufacturing sites and partners; travel to a transfer site may be required to support manufacturing activities.
• Collaborate with process and analytical chemists on synthetic strategy and route development.
• Develop and implement new technologies to improve processes at external manufacturing partners.
• Maintain knowledge of laboratory data-management systems and apply suitable modeling tools to gain process understanding from data-rich experiments.
• Stay current with process engineering and chemistry literature; potentially collaborate on and author external publications and present research at external conferences.
• Help build a safe, inclusive, and innovative culture in engineering and chemistry laboratories.
• Work collaboratively and effectively, building and leading high-performing teams.
• Document experimental work accurately and promptly, and clearly present work to internal and external stakeholders.
• Identify opportunities to align, share, and implement best practices across sites.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holidays, and personal days.
• Paid caregiver/parental and medical leave.
• Medical, prescription drug, dental, and vision coverage.
• Eligibility for a 12.5% target bonus through Pfizer’s Global Performance Plan.
• Eligibility to participate in a share-based long-term incentive program.
• Relocation assistance may be available based on business needs and eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior