Senior Scientist, Bioanalytics

Sutro Biopharma•South San Francisco, CA

3d•Onsite

About The Position

Sutro Biopharma is seeking a highly motivated and experienced Senior Bioanalytical Scientist to join its Preclinical Development team in South San Francisco, CA. The successful candidate will lead the design and execution of bioanalytical strategies for discovery, preclinical, and early clinical development programs. S/he will be responsible for developing and qualifying bioanalytical methods for small molecules and antibody-drug conjugates (ADCs), including drug-to-antibody ratio (DAR) assessment, and transferring these methods to CROs to enable preclinical and clinical studies. This role requires deep expertise in LC-MS/MS-based bioanalysis and a proven track record of independently driving complex programs in a fast-paced, collaborative environment. Sutro Biopharma, Inc. is advancing a next-generation antibody-drug conjugate (ADC) platform designed to deliver single- and dual-payload ADCs that enable meaningful breakthroughs for patients with cancer. By fully optimizing the antibody, linker, and payload, Sutro’s cell-free platform produces ADCs that are engineered to improve drug exposure, reduce side effects, and expand the range of treatable tumor types. With unique capabilities in dual-payload ADCs, Sutro aims to overcome treatment resistance and redefine what’s possible in cancer therapy. The Company’s pipeline of single- and dual-payload ADCs targets large oncology markets with limited treatment options and significant need for improved therapies.

Requirements

Ph.D. in PK/ADME, analytical chemistry, or a related field with 7+ years of relevant industry experience (biologics and small molecules)
Exceptional candidates without a Ph.D. with 12+ years of relevant experience may be considered
Proven track record of developing and optimizing quantitative bioanalytical methods for small molecules, biologics, and conjugates
Strong expertise in LC-MS instrumentation, including triple quadrupole and high-resolution mass spectrometry
Hands-on experience with ADC bioanalysis, including DAR characterization
Demonstrated ability to independently establish new experimental protocols using novel methods or techniques
Familiarity with PK analysis and interpretation
Working knowledge of regulatory guidance (FDA, ICH) relevant to bioanalytical and DMPK studies
Experience with LIMS and common analytical/data processing software
Demonstrated ability to author technical reports supporting regulatory filings, patents, and publications
Excellent communication skills and ability to thrive in a collaborative, cross-functional environment

Nice To Haves

Experience with ligand-binding assays is a plus
Experience developing automated sample handling and assay workflows is preferred

Responsibilities

Lead and implement bioanalytical (BA) strategies to address key scientific questions across discovery, preclinical, and early clinical programs
Develop stage-appropriate LC-MS/MS-based bioanalytical methods to quantify antibodies, ADCs, and small molecules in various biological matrices
Transfer bioanalytical methods to CROs and serve as the primary scientific lead overseeing external studies
Manage CRO relationships to ensure high-quality data delivery, adherence to timelines, and alignment with program goals
Assess in vitro and in vivo drug-to-antibody ratio (DAR) stability using high-resolution mass spectrometry
Analyze, interpret, and clearly communicate DMPK/BA data to internal project teams, senior leadership, and external collaborators
Author high-quality DMPK/BA reports to support IND submissions, regulatory filings, patent applications, and publications
Mentor and supervise junior bioanalytical scientists as needed
Serve as a functional representative on cross-functional project teams, including partnered programs
Contribute to the development of organizational processes, infrastructure, and resource planning, including capital equipment and budget considerations