SENIOR SCIENTIST, BIOANALYTICS

Sutro Biopharma • South San Francisco, CA

7d

About The Position

Sutro Biopharma is seeking a highly motivated and experienced Senior Bioanalytical Scientist to join its Preclinical Development team in South San Francisco, CA. The successful candidate will lead the design and execution of bioanalytical strategies for discovery, preclinical, and early clinical development programs. S/he will be responsible for developing and qualifying bioanalytical methods for small molecules and antibody-drug conjugates (ADCs), including drug-to-antibody ratio (DAR) assessment, and transferring these methods to CROs to enable preclinical and clinical studies. This role requires deep expertise in LC-MS/MS-based bioanalysis and a proven track record of independently driving complex programs in a fast-paced, collaborative environment.

Requirements

• Ph.D. in PK/ADME, analytical chemistry, or a related field with 7+ years of relevant industry experience (biologics and small molecules)
• Exceptional candidates without a Ph.D. with 12+ years of relevant experience may be considered
• Proven track record of developing and optimizing quantitative bioanalytical methods for small molecules, biologics, and conjugates
• Strong expertise in LC-MS instrumentation, including triple quadrupole and high-resolution mass spectrometry
• Hands-on experience with ADC bioanalysis, including DAR characterization
• Demonstrated ability to independently establish new experimental protocols using novel methods or techniques
• Familiarity with PK analysis and interpretation
• Working knowledge of regulatory guidance (FDA, ICH) relevant to bioanalytical and DMPK studies
• Demonstrated ability to author technical reports supporting regulatory filings, patents, and publications
• Excellent communication skills and ability to thrive in a collaborative, cross-functional environment

Nice To Haves

• Experience with ligand-binding assays is a plus
• Experience developing automated sample handling and assay workflows is preferred
• Experience with LIMS and common analytical/data processing software

Responsibilities

• Lead and implement bioanalytical (BA) strategies to address key scientific questions across discovery, preclinical, and early clinical programs
• Develop stage-appropriate LC-MS/MS-based bioanalytical methods to quantify antibodies, ADCs, and small molecules in various biological matrices
• Transfer bioanalytical methods to CROs and serve as the primary scientific lead overseeing external studies
• Manage CRO relationships to ensure high-quality data delivery, adherence to timelines, and alignment with program goals
• Assess in vitro and in vivo drug-to-antibody ratio (DAR) stability using high-resolution mass spectrometry
• Analyze, interpret, and clearly communicate DMPK/BA data to internal project teams, senior leadership, and external collaborators
• Author high-quality DMPK/BA reports to support IND submissions, regulatory filings, patent applications, and publications
• Mentor and supervise junior bioanalytical scientists as needed
• Serve as a functional representative on cross-functional project teams, including partnered programs
• Contribute to the development of organizational processes, infrastructure, and resource planning, including capital equipment and budget considerations

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree