Senior Scientist, Antibody Conjugation

Nurix•Brisbane, CA

2d•$155,000 - $180,000•Onsite

About The Position

We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies. This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material.

Requirements

PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization

Nice To Haves

Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.

Responsibilities

Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.