Senior Scientist, Analytical Development - Stem Cell & Metabolomics

Genentech • Daly City, CA

6d • $104,700 - $194,400 • Onsite

About The Position

Genentech’s Analytical Development & Quality Control (ADQC) team is expanding. As a core division within Genentech’s Pharma Technical Cell & Gene Therapy organization, we ensure the safety, efficacy and quality of cell therapies. ADQC develops, validates and executes advanced physiochemical, immunochemical and biological testing methods for clinical and commercial release. We are seeking a highly motivated and innovative Senior Scientist to join our team. This unique role bridges the fields of metabolomics and stem cell biology. You will lead initiatives aimed at understanding the metabolic rewiring, mitochondrial dynamics, and energy homeostasis that govern stem cell pluripotency, differentiation, and disease modeling. The ideal candidate possesses deep hands-on expertise in human pluripotent stem cell (hPSC) culture alongside advanced physiological assays to measure mitochondrial respiration and metabolic flux.

Requirements

• PhD in Cell Biology, Biochemistry, Bioengineering, or a related field; or a Master’s in Cell Biology, Biochemistry, Bioengineering, or a related field with 3+ years of relevant academic/industry experience.
• Demonstrated experience working at the bench. This is a bench scientist position, with the majority of the time (75%+) active at the bench, executing experiments daily.
• Demonstrated level of biological domain expertise in the metabolism space. Deep understanding of cellular energetics, mitochondrial function, or metabolic flux assays.
• Demonstrated level of expertise in stem cell biology. Ability to culture, differentiate and characterize iPSCs, MSCs, or primary cells.

Nice To Haves

• PhD in Stem Cell Biology, Biochemistry, or a related field
• CMC Experience - a proven track record of developing assays within a CMC/regulatory framework (understanding phase-appropriate validation, ICH guidelines, etc.).
• High level of familiarity with flow cytometry, qPCR/ddPCR, ELISA, and metabolic flux analyzers (e.g., Seahorse).
• Demonstrated strong interpersonal and communication skills with the ability to communicate technical knowledge in a clear and understandable manner, especially to non-experts; excel at problem-solving skills and the ability to work under ambiguous situations.
• Excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; complete work in a timely, accurate and thorough manner.

Responsibilities

• Stem Cell Biology: Experience with cell culture including differentiation of human iPSCs/ESCs into specific lineages to study metabolic shifts in hPSC derived cell therapy product manufacturing
• Cell Bioenergetic Profiling: Design and execute real-time functional metabolic assays to measure oxygen consumption rate (OCR) and extracellular acidification rate (ECAR)
• Mitochondrial Characterization: Evaluate mitochondrial function, membrane potential, dynamics (fission/fusion), biogenesis, and ROS production in stem-cell-derived models
• Metabolic Flux Analysis: Perform and analyze tracer-based experiments to map functional nutrient utilization (glucose, fatty acids, amino acids) during cell fate transitions in partnership with LC-MS specialists
• Documentation & Reporting: Maintain detailed laboratory notebooks, draft standard operating procedures (SOPs), and present functional metabolic data to cross-functional teams

Benefits

• Relocation benefits are not being offered for this role.
• Discretionary annual bonus may be available based on individual and Company performance.
• Benefits detailed at the link provided below.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior