Analytical Development Senior Scientist

Vertex Inc.•Boston, MA

21h•$122,400 - $183,600•Onsite

About The Position

Vertex is seeking a Senior Research Scientist to join Analytical Development in Boston, MA. This role supports the advancement of transformative medicines by leading analytical chemistry activities across all stages of clinical development. The position is part of the Chromatography Subject Matter Expert (SME) team, focused on small molecules and synthetic peptides/oligonucleotides, with particular emphasis on drug substance, drug product intermediates, and drug product.

Requirements

Deep experience in analytical method development and validation.
Strong technical expertise in chromatography and related analytical techniques, including GC, LC, GC-MS, LC-MS, Karl Fischer, and spectroscopy.
Proven ability in troubleshooting, data review, and interpretation.
Strong understanding of pharmaceutical industry regulations, guidelines, and GMP practices.
Excellent organizational, project management, written, and verbal communication skills.
Ability to explain technical concepts clearly and influence diverse stakeholders.
Effective in both team-based/matrix environments and independent work.
Able to manage multiple priorities in a fast-paced environment while maintaining timelines and quality.
Strong attention to detail.
Demonstrated ability to mentor others, advance projects through scientific insight, and identify productive new experimental approaches.

Responsibilities

Lead chromatographic method development, qualification, and validation activities.
Partner with cross-functional project teams to design, oversee, and review analytical methods, validation protocols, and reports.
Serve as a technical expert in chromatographic instrumentation and method development, including specialized detectors, column screening, forced degradation, and robustness studies.
Drive continuous improvement in phase-appropriate analytical development and validation practices.
Ensure consistent, compliant method development and validation practices across the organization.
Design and execute complex, technically challenging experiments that support departmental and project goals.
Interpret data, draw evidence-based conclusions, and assess broader implications of findings.
Develop innovative solutions to technical challenges and provide scientific guidance to team members when needed.
Contribute meaningfully to project strategy and critical scientific activities within the discipline.
Help build organizational capability through staff training, mentorship, and knowledge sharing.
Apply concepts or approaches from other fields to advance scientific progress.
Perform other duties as assigned.