Senior Scientist, Analytical Development and Quality Control

Serif Biomedicines•Cambridge, MA

About The Position

Serif Biomedicines is seeking a highly motivated, experienced Senior Scientist to join its Analytical Development and Quality Control team. The role leads method development, optimization, qualification, and implementation to characterize novel nucleic acid therapeutics and lipid nanoparticle (LNP) delivery vehicles, and supports release, stability, and characterization of nucleic acid cargo and LNP products. The Senior Scientist will help advance platform development and shape the team’s analytical capabilities through hands-on laboratory work, technical leadership, and mentorship of junior colleagues. The position includes planning and executing experiments, optimizing analytical method performance, troubleshooting assays and instruments, and supporting routine analytical testing and process-development activities. The successful candidate will communicate findings to internal teams and cross-functional stakeholders, contribute technical input to regulatory filings, and author and manage protocols, laboratory data, and technical reports. The role is based in a dynamic, fast-paced, entrepreneurial, and highly collaborative multidisciplinary environment. Serif Biomedicines is an early-stage biotechnology company developing a gene therapy approach for currently untreatable diseases. It was founded by Flagship Pioneering, which creates and grows life-sciences companies focused on human health and sustainability. The salary range is $126,000–$181,500. Compensation depends on qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, an annual incentive program, retirement benefits, and other benefits.

Requirements

Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, or a related field.
Relevant industry experience: 14 or more years with a B.S., 12 or more years with an M.S., or 5 or more years with a Ph.D.
Prior hands-on experience working with mRNA/DNA cargo and LNP products.
Technical expertise in HPLC separations or LC-MS, with a track record of independently developing and troubleshooting analytical methods.
Ability to independently design, execute, and troubleshoot complex experiments.
Strong communication and organizational skills.
Working knowledge of Benchling, MS Office, JMP, GraphPad, Empower, and Chromeleon.
Attention to detail, meticulous record keeping, and personal organization.
Ability to analyze, compile, and present experimental data in oral presentations and technical reports.
Strong technical writing skills for method SOPs, protocols, and reports.
Ability to lead cross-functional technical initiatives and represent the ADQC team in scientific discussions.

Nice To Haves

Experience with plate-based assays.
Experience mentoring, training, or providing technical guidance to junior staff.

Responsibilities

Lead the team’s advancement of platform development and contribute to shaping analytical capabilities.
Perform hands-on laboratory work to execute platform goals, while providing technical direction and mentorship to junior team members.
Lead method development and implementation supporting nucleic acid cargo and LNP product release, stability, and characterization.
Lead experimental studies to optimize analytical methods for specificity, sensitivity, precision, accuracy, and/or linearity.
Troubleshoot assay-development and instrument-operation issues and serve as a technical resource for the broader team.
Plan experiments, design studies, and schedule development projects and routine testing across programs.
Support day-to-day analytical analysis for process-development activities to ensure robust process and product characterization.
Work independently and collaboratively in a multidisciplinary team, providing technical guidance and mentorship to junior colleagues.
Analyze, troubleshoot, and communicate experimental findings clearly in oral, written, and visual formats to internal teams and cross-functional stakeholders.
Provide technical input to support regulatory filings.
Author and manage protocols, laboratory data, and technical reports.
Lead cross-functional technical initiatives and represent the Analytical Development and Quality Control team in scientific discussions.