Senior Scientist, Analytical Development and Quality Control

Serif Biomedicines, Inc.•Cambridge, MA

9d•$126,000 - $181,500

About The Position

Serif Biomedicines is seeking a Senior Scientist to join its Analytical Development and Quality Control team. The role leads the development, optimization, implementation, and qualification of analytical methods for characterizing novel nucleic acid therapeutics and lipid nanoparticle (LNP) delivery vehicles, including support for product release, stability, and characterization. The Senior Scientist will contribute to advancing the team’s analytical platform, perform hands-on laboratory work, troubleshoot assays and instruments, and provide technical direction and mentorship to junior colleagues. The position works across a collaborative, multidisciplinary team in a dynamic, fast-paced, entrepreneurial environment. The role also supports process development through analytical testing and robust process and product characterization; plans and schedules development studies and routine testing; communicates experimental findings to internal and cross-functional stakeholders; provides technical input for regulatory filings; and authors and manages protocols, laboratory data, and technical reports. Serif Biomedicines is an early-stage biotechnology company developing a gene therapy approach for diseases that are currently untreatable. It was founded by Flagship Pioneering, which creates and develops life sciences companies focused on human health and sustainability. The position offers a salary range of $126,000–$181,500. Serif currently offers healthcare coverage, an annual incentive program, retirement benefits, and other benefits.

Requirements

Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, or a related field.
Relevant industry experience: 14 or more years with a B.S., 12 or more years with an M.S., or 5 or more years with a Ph.D.
Prior hands-on experience working with mRNA/DNA cargo and LNP products.
Technical expertise in HPLC separations or LC-MS, with a track record of independently developing and troubleshooting analytical methods.
Ability to independently design, execute, and troubleshoot complex experiments.
Strong communication and organizational skills.
Working knowledge of Benchling, MS Office, JMP, GraphPad, Empower, and Chromeleon.
Attention to detail, meticulous record keeping, and personal organization.
Ability to analyze, compile, and present experimental data in oral presentations and technical reports.
Strong technical writing skills for method SOPs, protocols, and reports.
Ability to lead cross-functional technical initiatives and represent the team in scientific discussions.

Nice To Haves

Experience with plate-based assays.
Experience mentoring, training, or providing technical guidance to junior staff.

Responsibilities

Lead advancement of platform development and help shape the team’s analytical capabilities, including performing hands-on benchwork and mentoring junior team members.
Lead method development and implementation for nucleic acid cargo and LNP product release, stability, and characterization.
Lead experimental studies to optimize analytical-method specificity, sensitivity, precision, accuracy, and/or linearity.
Troubleshoot assay-development and instrument-operation issues and serve as a technical resource for the broader team.
Plan experiments, design studies, and schedule development projects and routine testing across programs.
Support day-to-day analytical analysis for process development to ensure robust process and product characterization.
Work independently and collaboratively in a multidisciplinary team, providing technical guidance and mentorship to junior colleagues.
Analyze, troubleshoot, and clearly communicate experimental findings in oral, written, and visual formats to internal teams and cross-functional stakeholders.
Provide technical input to support regulatory filings.
Author and manage protocols, laboratory data, and technical reports.
Lead cross-functional technical initiatives and represent the Analytical Development and Quality Control team in scientific discussions.