Senior Research Technologist-Rochester Flow Cytometry Core

Mayo Clinic • Rochester, MN

11d • Onsite

About The Position

The Optical Microscopy and Cell Analysis Core is seeking a motivated individual to support flow cytometry-based research projects across the Mayo Clinic enterprise. The successful candidate will be responsible for day-to-day instrument calibration, sample acquisition and high-speed cell sorting, data management and backup, routine maintenance, quality control, and troubleshooting of flow cytometry instrumentation. The individual will train and assist researchers with experimental design, multicolor flow cytometry panel development and optimization, instrument setup, and interpretation of flow cytometry data. Additional responsibilities include supporting assay development, data analysis using platforms such as FlowJo, maintaining detailed records and standard operating procedures, and ensuring a safe, organized, and collaborative core facility environment. Experience with conventional and/or spectral flow cytometry platforms and the ability to provide technical support for multiple research projects are highly desirable. This is a limited tenure position that has been approved for two years that may have the possibility of turning into a regular position. This vacancy is not eligible for sponsorship. We will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.

Requirements

• Requires bachelor's degree in biology, chemistry, or other relevant science with 4 years of research laboratory experience.
• Demonstrated expertise in multicolor flow cytometry panel design, optimization, and troubleshooting, including experience with high-parameter conventional and/or spectral flow cytometry.
• Ability to develop and validate complex panels, identify technical issues, and implement solutions to ensure high-quality and reproducible data.
• Hands-on experience operating and maintaining flow cytometry instrumentation, including platforms such as BD Biosciences, Cytek, Bio-Rad, or equivalent systems.
• Strong knowledge of experimental design, assay development, and flow cytometry data analysis.
• Experience using software such as FlowJo or similar platforms to support investigators with study design, data interpretation, compensation, spectral unmixing, and validation of research assays.
• Experience working in a shared resource, core facility, or collaborative research environment supporting multiple users and projects simultaneously.
• Demonstrated ability to prioritize workflows, maintain detailed records, develop standard operating procedures, and provide technical support in a service-oriented setting.

Nice To Haves

• Master's degree in biology, chemistry, or other relevant science preferred.
• Experience performing routine quality control, instrument performance monitoring, basic troubleshooting, and coordinating preventive maintenance and service activities is preferred.
• Candidates who have published first-author peer-reviewed research articles demonstrating the development, optimization, or application of multicolor flow cytometry panels will be given special consideration.

Responsibilities

• Independently sets up and performs experiments and procedures in support of lab goals and grant commitments (e.g. assays, cell/tissue culture, animal studies, etc.).
• Contributes to the planning, design and modification of studies and experiments in the research lab setting.
• Monitors results, reports unusual outcomes and suggests modifications.
• Collects, enters, summarizes, and analyzes data.
• May oversee and assist with the training of residents, fellows and temporary lab personnel in lab techniques.
• Works with minimal supervision and performs assignments independently as discussed and approved by Principal Investigator.
• Responsible for day-to-day instrument calibration, sample acquisition and high-speed cell sorting, data management and backup, routine maintenance, quality control, and troubleshooting of flow cytometry instrumentation.
• Train and assist researchers with experimental design, multicolor flow cytometry panel development and optimization, instrument setup, and interpretation of flow cytometry data.
• Supporting assay development, data analysis using platforms such as FlowJo, maintaining detailed records and standard operating procedures, and ensuring a safe, organized, and collaborative core facility environment.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior