Senior Research Technician

Bexorg•New Haven, CT

5d•$39•Onsite

About The Position

Bexorg is hiring an experienced bench lead for day-to-day culture, assay, and imaging work on its NeuroScale team in New Haven, Connecticut. The Senior Research Technician independently runs methods from start to finish, troubleshoots failures, writes and maintains protocols, trains junior technicians, and helps improve and standardize methods as the team grows. The role is on-site, full-time, and includes rotating night shifts and weekends. It reports to the Wet-Lab Lead, NeuroScale. Pay is listed as 38.50 plus a night-shift differential; no pay period or currency is specified. The position supports precision neurology research through work involving human brain tissue, cell and tissue culture, drug screening, molecular assays, tissue processing, and fluorescence imaging. The technician coordinates bench schedules with scientists, maintains data quality and complete records, cares for key instruments, prepares samples for external partners, and manages laboratory supplies, organization, and safety practices.

Requirements

Bachelor's degree in biology, neuroscience, biomedical engineering, or a related field; alternatively, an associate degree with equivalent hands-on experience.
At least 5 years of hands-on work as a research or laboratory technician in an academic, hospital, or industry laboratory; 7 or more years if qualifying with an associate degree.
Demonstrated ability to independently perform cell or tissue culture, fluorescence microscopy, qPCR, and at least one plate-based viability or metabolic assay, such as CellTiter-Glo or lactate assays.
Hands-on cryosectioning of fixed or frozen tissue.
Experience writing SOPs and training others at the bench.
Willingness to work and lead rotating night shifts and weekends.
Comfort working with human post-mortem tissue under biosafety level 2 (BSL-2) practices.
Steady hands and close attention to detail when handling delicate tissue.
Careful, organized record keeping.
Ability to plan and prioritize work with minimal supervision and communicate clearly with scientists and engineers.
Can-do attitude.

Nice To Haves

Experience with RNAscope on tissue sections and multiplex immunofluorescence.
Experience with organotypic slice culture, primary neural culture, or human brain or other human tissue.
Experience with drug screening and compound handling in 96- or 384-well formats, including liquid handlers.
Experience in an industry or regulated setting, such as GLP, using an electronic lab notebook (ELN) or laboratory information management system (LIMS).
Experience in a core facility, cell bank, or quality-control laboratory.
Basic image analysis using Fiji (ImageJ) or similar tools.

Responsibilities

Independently run and troubleshoot organotypic human brain slice culture, cell culture, multi-well drug screening, CellTiter-Glo, pyruvate and lactate assays, qPCR, RNAscope, cryosectioning, immunofluorescence staining, and fluorescence imaging.
Write, test, and maintain standard operating procedures (SOPs) for laboratory methods.
Plan weekly bench schedules with scientists, including plate layouts, dosing schedules, assay time points, and imaging slots.
Lead rotating night shifts and respond to culture or equipment problems outside regular hours.
Train junior technicians, assess their skills in each method, and sign off on their ability to work independently.
Ensure data quality by checking controls, flagging outliers and failed runs, and maintaining assay performance logs.
Maintain complete and accurate sample, treatment, and results records in electronic lab notebooks and sample-tracking systems.
Maintain key instruments through routine care, calibration checks, and coordination of vendor service visits.
Collaborate with the engineering team to improve and standardize laboratory methods, and test changes at the bench.
Prepare and ship samples to outside partners using correct labels, dry-ice packing, and chain-of-custody records.
Manage laboratory stock and ordering, maintain work-area organization, and follow safety practices.