Senior Research Scientist, Oncology

This position is responsible for conducting independent experiments in an oncology laboratory focused on PROTAC-based drug discovery. The role requires strong molecular biology skills, knowledge of cancer genetics, and experience in gene and chromatin regulation. The successful candidate will collaborate with team members across multiple functional areas, execute high-quality assays, and contribute to program progression. This is a laboratory-based role that requires exceptional experimental skills, multitasking abilities, and a proactive attitude. The position reports to a Principal Research Investigator and is located at the company's headquarters in New Haven, CT.

• Conduct experiments independently towards PROTAC based drug discovery in an oncology laboratory
• Leverage multiple assay platforms in molecular biology to measure, understand and interpret target engagement, pathway modulation, and cell sensitivity in response to small molecule treatment/target modulation
• Execute high-quality standard analytical assays with excellent technical proficiency and troubleshooting skills
• Perform cellular functional assays such as 2D/3D cellular proliferation assays, cytotoxicity assays, apoptosis assays, siRNA/shRNA knockdown assays
• Independently select methods, design, execute, analyze, and interpret own cell-based experiments using various cell culture plate formats
• Design, QC, validate, and execute medium- to high-throughput 96/384 well assay formats
• Interact and collaborate with biology and chemistry team members to facilitate program progression
• Provide advice and troubleshooting help to others in the lab
• Maintenance of cell lines for own experiments, ensuring QC of and LN stocks are maintained and catalogued appropriately
• Document, compile, and interpret experimental data; manage laboratory notebook, databases, and/or spreadsheets
• Present data to peers and senior colleagues
• Timely planning of experiments to ensure availability of lab reagents and resources in advance

• Background in cancer genetics, transcription factors, gene and chromatin regulation
• Exceptional experimental skills
• Ability to effectively partner with team members across multiple functional areas
• Multitasking abilities
• Intellectual curiosity
• Excellent molecular biology skills
• Knowledge in the biology of oncogenesis
• "Nothing is impossible" attitude
• Experience in independent decision making, troubleshooting, experimental design, and implementing and executing studies
• Proficiency in multiple assay platforms in molecular biology (TR-FRET, DNA/RNA isolation, PCR, RT-PCR, qRT-PCR, gene expression methodologies, IP, ChIP)
• Proficiency in standard analytical assays (Western blots, ELISA, MSD)
• Proficiency in cellular functional assays (2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA knockdown assays)
• Ability to independently select methods, design, execute, analyze, and interpret cell-based experiments using various cell culture plate formats with suspension and adherent cell lines
• Ability to design, QC, validate, and execute medium- to high-throughput 96/384 well assay formats (proliferation assays/cytotoxicity/apoptosis assays)
• Collaboration and interaction with biology and chemistry team members
• Troubleshooting skills and ability to provide advice and interpretation to others in the lab
• Maintenance of cell lines and ensuring quality control and cataloging
• Documentation, data interpretation, and presentation skills
• Timely planning of experiments and resource management.

• Competitive base and incentive compensation
• Comprehensive benefits program
• Group medical, vision, and dental coverage
• Group and supplemental life insurance
• Health and wellness support
• Financial security support
• Opportunity for career advancement and growth
• Collaborative and diverse work environment
• Opportunity to work on cutting-edge technology and research
• Opportunity to make a significant impact in the field of targeted protein degradation therapeutics
• Opportunity to work with a passionate and innovative team
• Opportunity for professional development and learning
• Access to specialized instrument software
• Work-life balance
• Equal opportunity employment