Senior Research Investigator, Pharmacometrics

Bristol Myers Squibb • Princeton, NJ

11d

About The Position

The Senior Pharmacometrician develops and implements model-informed drug development (MIDD) plans for drugs and other therapeutic agents in clinical development, partnering with Clinical Pharmacology (CP) and other quantitative functions. MIDD integrates diverse data through pharmacometrics (PMx) models to inform development decisions and regulatory assessments. Applications include dose and regimen selection, clinical study hypotheses, clinical pharmacology and benefit-risk assessments, and health authority interactions. Model-based analyses may also support approval decisions or, in some cases, serve as the primary basis for approval. Model-based meta-analysis (MBMA) provides a quantitative view of competitors and comparators.

The role applies PMx methods including population pharmacokinetics/pharmacodynamics, exposure-response, disease progression, and MBMA. Knowledge of modern approaches such as mechanistic modeling (QSP and PBPK), scientific machine learning, and agentic workflows is a significant bonus. The position includes planning, conducting, and reporting analyses, collaborating across functions, contributing to methods and infrastructure, and supporting health authority interactions, generally with some supervision.

The position is based in Princeton, New Jersey. Local and international travel for conferences and regulatory meetings may be required depending on project needs, up to 5–10% of the time. The role is identified as #LI-Hybrid, though the posting describes several work models and does not specify the assigned model for this role.

Requirements

• Advanced degree in a relevant field: MS, PhD, or PharmD.
• At least 2 years of experience with demonstrated progression in PMx and Clinical Pharmacology knowledge.
• Basic quantitative data analysis, data wrangling (merging and transforming data), and visualization skills.
• Advanced population pharmacokinetics and exposure-response skills.
• Programming experience with R, NONMEM, Monolix, Pumas, Matlab, Python, or Julia.
• General knowledge of the drug development process.
• Knowledge of current practices and issues in PMx and Clinical Pharmacology.
• Strong written and oral communication skills to report scientific findings and deliver presentations.
• Demonstrated ability to work in a dynamic, team-oriented environment.

Nice To Haves

• Knowledge of mechanistic modeling is desired.
• Understanding of modern PMx approaches such as QSP, PBPK, scientific machine learning, and agentic workflows is a significant bonus.

Responsibilities

• Partner with the Clinical Pharmacology lead to specify MIDD components of the PMx plan.
• Work with other quantitative disciplines to formulate and execute a coherent modeling and data plan.
• Plan, execute, and report formal PMx analyses for clinical study reports, health authority submissions, and responses to health authority questions.
• Serve as an MIDD subject matter expert, working with the CP lead and other quantitative functions in therapeutic agent development.
• Contribute to maintaining and refining PMx infrastructure.
• Contribute to PMx and cross-functional initiatives.
• Manage PMx analyses performed by vendors.
• Participate in interactions with health authorities as an MIDD subject matter expert.
• Collaborate with internal and external subject matter experts to develop and enhance MIDD methodology and capability.

Benefits

• Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings, subject to plan terms and eligibility.
• Flexible Time Off (FTO) without a set accrual limit for eligible U.S.-based exempt employees, subject to manager approval.
• For specified non-exempt employees, RayzeBio employees, and employees located in Puerto Rico: 160 hours of paid vacation annually for new hires, subject to manager approval.
• 11 paid company holidays each year; specified employee groups also receive 3 optional holidays.
• Depending on eligibility, paid sick leave, up to two paid volunteer days per year, summer-hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.
• Potential eligibility for discretionary cash incentives and stock opportunities.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior