Senior Research Associate

Proxima • Boston, MA

21h

About The Position

Proxima is seeking a hands-on Senior Research Associate to join its NeoLink Platform team and execute proteomics experiments that support its structural interactomics platform. The role focuses on end-to-end proteomics sample preparation and LC-MS workflows, learning routine maintenance of next-generation mass spectrometry instrumentation, and contributing to the scale-up of proteome-wide interaction mapping. The associate will work with proteomics scientists, computational biologists, and chemists to generate proprietary data that trains Neo and supports Proxima’s drug discovery pipeline.

Requirements

• Bachelor’s or Master’s degree in Biochemistry, Chemistry, Biology, or a related scientific discipline.
• At least 5 years of hands-on industry experience in a drug discovery, proteomics, or analytical chemistry setting.
• Demonstrated proficiency in mass spectrometry-based proteomics workflows, including required hands-on sample preparation and LC-MS experience.
• Strong troubleshooting skills and excellent attention to detail.
• Ability to independently manage multiple experiments and timelines in a fast-paced environment.
• Excellent organizational skills and strong record keeping.

Nice To Haves

• Prior biotech or pharmaceutical industry experience in a platform or drug discovery environment.
• Experience operating Orbitrap-class instruments, such as Astral, Exploris, Eclipse, or similar.
• Familiarity with proteomics data analysis tools such as Proteome Discoverer, MaxQuant, Skyline, or FragPipe.
• Experience with click chemistry enrichment and affinity-tag-based peptide capture.
• Experience with automated sample preparation platforms such as Hamilton or Opentrons.

Responsibilities

• Execute proteomics experiments end-to-end, including sample preparation and LC-MS data acquisition.
• Own early target and hit validation workstreams to drive drug discovery efforts.
• Operate and maintain LC-MS systems, including routine column installation, source cleaning, calibration, and system performance QC.
• Troubleshoot experimental and instrument issues and contribute to continuous improvement of sample preparation workflows.
• Maintain accurate experimental records in the electronic lab notebook and adhere to strong documentation standards.
• Collaborate with computational biologists, chemists, and other scientists to integrate proteomics data into structural biology and drug discovery workflows.
• Complete compound management workflows.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior