Senior Research Associate, Preclinical Pharmacology

Nurix•Brisbane, CA

2d•$131,400 - $139,900•Onsite

About The Position

Join the Research – Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology. Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection. Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads. Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly. Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses. Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation. Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues. Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation. Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings. Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays. Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications. Contribute to the optimization and qualification of new models and assays and to the training of junior team members. Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned; minimal travel (<5%).

Requirements

BS/MS in Biology, Pharmacology, Immunology, Cancer Biology, or a related field, with a BS or equivalent plus 8 or more years of relevant experience, or an MS plus 4 or more years of relevant experience
Industry (biotech or pharma) experience conducting in vivo pharmacology studies in mice
Proficiency in mouse handling and dosing by PO, IP, SC, and IV routes, as well as blood collection and tissue harvest
Hands-on experience with oncology models (e.g., xenograft, syngeneic) and with murine models of inflammation or immunology
Demonstrated proficiency in Western blotting and flow cytometry, including sample preparation, staining, and data analysis
Proficiency in sterile mammalian cell culture technique
Working knowledge of IACUC regulations and humane animal care practices
Strong organizational and documentation skills, with attention to detail and the ability to manage multiple studies simultaneously
Collaborative, adaptable, and comfortable in a fast-paced, team-oriented research environment
Ability to work in an animal facility and tolerate exposure to laboratory animals, and to work occasional weekends or off-shift hours as studies require

Nice To Haves

experience with targeted protein degradation (molecular glues, PROTACs) or other small-molecule oncology or immunology programs
experience with multi-spectral flow cytometry, automated Western (e.g., Jess/Wes), ELISA, or MSD cytokine/biomarker assays
experience with orthotopic, disseminated, PDX, or humanized mouse models, or with in vivo imaging
experience with inflammation models such as collagen-induced arthritis, colitis, or cytokine-challenge models
familiarity with PK/PD relationships, compound formulation, and dose-response study design
proficiency with GraphPad Prism and electronic lab notebook systems

Responsibilities

Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection
Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads
Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly
Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses
Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation
Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues
Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation
Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings
Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays
Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications
Contribute to the optimization and qualification of new models and assays and to the training of junior team members
Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned