Senior Research Associate, Neural Cell Production (Fixed-Term Contract)

Arc Institute • Palo Alto, CA

2h • $84,250 - $114,250 • Onsite

About The Position

We are seeking a Senior Research Associate, Neural Cell Production to join the Cellular Models Technology Center for a fixed term of 18 months to produce the stem cell-derived cell types that feed our ADI screening program (neural progenitor cells, neurons, astrocytes, and microglia) reliably and consistently to a high standard. This is a hands-on stem cell production role that requires the consistency, rigor, and reproducibility of a production setting. Beyond differentiation, you will QC each lot using our established pipeline (flow cytometry, proliferation, imaging, and/or functional assays), bank the QC'd cells, and keep complete registration and documentation in Benchling. Cell supply is the upstream foundation of every ADI screen: the reliability, quality, and timeliness of the cells you produce directly determine whether each screen can run and whether its data is interpretable. You will work in close collaboration with the scientists and research associates leading each production workflow to deliver the cells our high-cadence screening calendar depends on. This is a temporary contractor position based onsite 5 days a week in Palo Alto. This role is not eligible for visa sponsorship.

Requirements

• BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience
• Substantial experience culturing and maintaining human PSCs and differentiating them into defined cell types (NPCs, neurons, astrocytes, microglia, or similar), with reliable, reproducible results.
• Demonstrated ability to execute multiple cell culture protocols with precision and to transition between them accurately, maintaining fidelity to each protocol's specific requirements (workflow, media, and timeline).
• Experience QCing cells using cellular and/or molecular assays such as flow cytometry, DNA proliferation, or MEAs (experience with one or more of these; not all required).
• Excellent aseptic technique and consistent cell-culture practice held to a high, production-type standard.
• Experience with cryopreservation, thawing, expansion, and cell banking.
• Meticulous documentation and record-keeping; comfort working to a production schedule, and basic data tracking and analysis.
• Work onsite in our Palo Alto office 5 days per week.
• Occasional weekend work may be required.

Nice To Haves

• Background in an industry iPSC production setting (e.g., cell-products manufacturer, CDMO, or organoid/drug-discovery production group).
• Experience producing 3D brain organoids.
• Familiarity with Benchling or comparable ELN systems.

Responsibilities

• Produce stem cell-derived cell types for ADI such as neural progenitor cells (NPCs), neurons, astrocytes, and microglia, reliably and consistently, following established differentiation protocols.
• Master the distinct workflow, media composition, and protocol-specific requirements of each cell type, and transition between them dependably according to upcoming screening needs.
• Collaborate closely with the team members leading each production workflow to deliver the cell production required to support the screens.
• QC each lot using the established pipeline: flow cytometry, proliferation, imaging, and/or functional assays.
• Create banks of QC'd cells and manage their proper registration and documentation in Benchling.
• Maintain iPSC and progenitor cultures (feeding, passaging, expansion, cryopreservation, thawing) and coordinate production timing against the screening calendar.
• Follow and help maintain established protocols and SOPs, flagging issues to the workflow leads.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior