Pioneering Medicines: Senior Research Associate, In Vivo Pharmacology

Flagship Pioneering•Cambridge, MA

2d•Onsite

About The Position

Pioneering Medicines, a division of Flagship Pioneering, is seeking a Senior Research Associate for its In Vivo Pharmacology group. This role will be responsible for independently developing and performing studies using animal models across multiple disease areas, including oncology, autoimmunity, and metabolism. The position involves collaboration with in vitro biology, translational science, and nonclinical groups to execute company strategy. The unique approach of Pioneering Medicines allows for the combination of platforms to create novel and potentially transformative treatments for serious diseases with unmet medical needs.

Requirements

BSc or advanced degree in Biology or related disciplines with 2+ years of experience in animal handling within a research setting.
Expertise in multiple forms of substance administration (e.g., PO, IP, IV, SC).
Experience in necropsy, tissue collection and processing.
Demonstrated ability to execute or learn various in vitro and ex vivo assays (e.g., cell culture, ELISA, Flow cytometry).
Proficient in scientific software (e.g., Excel, GraphPad Prism, FlowJo).
Ability to analyze scientific data and clearly communicate summarized data to internal PM team members and stakeholders.
Accurately record detailed documentation of experimental results via ELN (Electronic Lab Notebook).
Ability to operate as part of a team and work with colleagues across the organization to advance projects at all stages.

Nice To Haves

Research background in oncology, immunology, or metabolism in an industry or academic setting preferred.
Previous experience with animal models of metabolism, oncology and autoimmunity preferred.
Hands-on experience with flow cytometry is a plus.

Responsibilities

Support the screening, characterization, and mechanism of action studies for drug candidates of various modalities, including small molecules, biologics and nucleic acids.
Generate high quality data using in vivo models of oncology, autoimmunity and metabolism.
Monitor animal health, accurately record data and comply with IACUC regulations in regard to animal welfare and care.
Help develop ex vivo assays in conjunction with translational science to determine relevant pharmacodynamic biomarkers and mechanism of action of targets/programs within PM.
Collaborate with colleagues within the larger in vivo group, in vitro biology, and translational teams to support PM’s daily operations in both the vivarium and the main laboratory.