Senior Research Associate, In Vivo Pharmacology

Abiologics•Watertown, MA

11d•$81,000 - $107,250

About The Position

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins™, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology. Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents. We are looking for a highly motivated, broadly skilled Senior Research Associate to join our growing Pharmacology team. In this role, the successful candidate will be responsible for hands-on execution of rodent in vivo studies as well as coordination of studies with contract labs to support the progression of Abiologics’ pipeline. The incumbent may also contribute to in vitro and ex-vivo pharmacology activities to progress projects and the platform, including molecular and cell biology assays and histology. This role will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company growth.

Requirements

BS in Biology or related discipline with 5–7 years of relevant research experience, or MS with 3–5 years of relevant experience, ideally in a biotech or pharmaceutical setting.
Well-established, independent experience with rodent in vivo dosing and handling techniques with expertise in multiple routes of substance administration (e.g., PO, IP, IV, SC) and ability to efficiently execute study protocols involving multiple blood collection time points.
Experience in tissue dissection and preparation for RNA, protein analysis, and histology, including fixation and embedding.
Demonstrated ability to execute or learn various molecular and cell biology techniques, such as ELISA, Western blot, qPCR, cell-based functional assays, and flow cytometry.
Proficiency with software such as Excel, GraphPad Prism, and PowerPoint for experimental documentation and data analysis/presentation.
Strong organizational and analytical problem-solving skills, with meticulous attention to detail and industry-level experience with best practices related to data documentation and integrity.
Demonstrated ability to work independently and collaboratively across highly skilled, cross-functional teams in a fast-paced, entrepreneurial, and technically complex environment.

Nice To Haves

Extensive experience in cell culture techniques, including primary cell isolation, culture, characterization.
Experience with tissue sectioning and immunohistochemistry techniques, including antibody validation, multiplexing, and imaging.
Experience in flow cytometry and data analysis (e.g., FlowJo) is a plus.

Responsibilities

Conduct in vivo (mouse) studies to characterize and assess the function, pharmacokinetics, and biodistribution of SynteinsTM, with increasing ownership of study design and interpretation.
Perform hands-on dosing of mice (including intravenous and other routes) and isolation/processing of mouse blood and tissues.
Comply with IACUC regulations regarding animal welfare and care.
Collect and prepare tissues for histology, including fixation and embedding.
Execute and optimize lab procedures such as tissue lysis and cell isolation, ELISA, Western blot, RNA/DNA extraction, qPCR, and related cell/molecular biology assays supporting in vivo studies, including some cell culture.
Coordinate with CROs to support the execution of external in vivo studies, including formulation and shipment of compounds.
Analyze, interpret, and accurately document study and assay results in an electronic lab notebook and present findings in internal meetings.
Apply troubleshooting and data analysis skills to resolve issues and improve study quality and throughput.
Collaborate with the Pharmacology team and cross-functionally to support lead optimization and platform advancement.