Senior Research Associate, in vivo Pharmacology

Stoke Therapeutics•Bedford, MA

10d•$98,000 - $110,000•Onsite

About The Position

Stoke Therapeutics is seeking a highly skilled and enthusiastic Senior Research Associate in In Vivo Pharmacology to join our preclinical research team. This individual will be instrumental in the execution of in vivo studies in a fast-paced and exciting environment working with rodent models in the CNS and other therapeutic programs. This position will report to the Associate Director of In Vivo Strategy and Operations.

Requirements

B.S. with 4 years of experience or M.S. with 2 years of experience (relevant industry experience is a plus).
Degrees in Pharmacology, Neuroscience or relevant disciplines highly preferred.
Proficient in various routes of dose administration in mice and rats including, but not limited to, SC, IV, IT and ICV.
Experience with PK/PD studies in rodents
Extensive knowledge of rodent anatomy to perform large scale necropsies
Experience with anesthesia and pre- and post-op monitoring
Skilled in surgical techniques such as stereotaxic ICV injections
Knowledge with rodent behavioral studies of the CNS
Experience with breeding and colony management
Tissue processing and homogenization
qPCR, ELISA, MSD
Proficient with Excel, GraphPad Prism, and PowerPoint for data interpretation and presentation
Electronic Notebook
Familiarity with writing technical reports
Strong aptitude for adapting technological advances in the field

Nice To Haves

Serial sampling in rodents is a plus
Familiarity with Softmouse colony management Software is a plus

Responsibilities

Work cross-functionally with scientists to help design and execute complex in vivo rodent studies to advance Stoke’s preclinical pipeline using antisense oligonucleotides to restore protein expression.
Perform hands-on rodent procedures including bolus ICV and IT injections in both neonate and adult mice and rats. Other routes of injections include subcutaneous and intravenous injections with subsequent blood collection, serial sampling, and tissue collections.
Perform adult surgical procedures including dosing, anesthesia monitoring and pre/post-op preparations.
Execute dose-response, time-course, PK/PD, tolerability and efficacy studies.
Maintain breeding colonies, wean and genotype, and utilize Softmouse to help expand colonies for experiments.
Assess animal phenotypes by implementing various behavioral assays like Open Field, DigiGait, and Rotarod.
With a keen eye for attention to detail, prepare tubes for sample collections and perform necropsies and subsequent tissue homogenization and molecular biology assays.
Help analyze and interpret experimental data using appropriate statistical approaches and software.
Maintain accurate laboratory records, electronic notebooks, study protocols, and data reports.
Other tasks as assigned