Senior Research Associate, Fermentation Development

Flagship Pioneering, Inc.Cambridge, MA
$81,000 - $107,300Onsite

About The Position

We are seeking a highly motivated Senior Research Associate to support the development and optimization of microbial fermentation processes for recombinant protein production. Reporting to the Principal Scientist, Bioprocess Development, this individual will play a key role in executing and scaling aerobic microbial fermentation workflows in a fast-paced startup environment. The ideal candidate is highly hands-on, technically rigorous, and comfortable operating independently in a dynamic research setting. This role requires strong practical experience with bench-scale bioreactors, microbial culture techniques, fermentation analytics, and laboratory operations.

Requirements

  • Bachelor’s degree (with 5-7 years of relevant research experience) or Master’s degree (with 3-5 years of relevant research experience) in Bioengineering, Chemical Engineering, Microbiology, Biotechnology, or related discipline.
  • Hands-on experience in microbial fermentation, microbiology, bioprocess development, or related laboratory environments
  • Experience in operating and maintaining bench-scale bioreactors
  • Strong understanding of aseptic technique and microbial culture handling
  • Experience with aerobic microbial fermentation workflows
  • Strong organizational and documentation skills
  • Ability to independently execute experiments and troubleshoot routine process issues

Nice To Haves

  • Experience with fed-batch fermentation processes
  • Familiarity with HPLC-based analysis of sugars, organic acids, or fermentation metabolites
  • Experience with recombinant protein expression systems
  • Experience supporting process optimization or scale-up activities
  • Familiarity with fermentation data analysis and process monitoring tools

Responsibilities

  • Operate, monitor, and troubleshoot bench-scale aerobic microbial fermentation systems with minimal supervision
  • Execute batch and fed-batch fermentation experiments to support process development objectives
  • Prepare media, inoculum, feeds, and process solutions for fermentation campaigns
  • Perform reactor setup, sterilization, calibration, and post-run cleaning/maintenance
  • Collect and process fermentation samples throughout cultivation runs
  • Perform routine analytical assays including OD measurements, metabolite analysis, and sample preparation for HPLC or related analytical platforms
  • Track fermentation performance metrics including biomass, substrate consumption, and product formation
  • Support screening and characterization of microbial strains in shake flask and bench scale bioreactors
  • Assist in process optimization studies, including media development and fermentation parameter evaluation
  • Maintain accurate and well-organized experimental records and documentation
  • Generate and maintain microbial cell banks and inventory records
  • Coordinate ordering and tracking of fermentation consumables and raw materials
  • Support routine laboratory maintenance, equipment upkeep, and troubleshooting
  • Contribute to safe laboratory operations and maintain a strong culture of safety and operational rigor
  • Collaborate with strain engineering, downstream, and analytical teams to support integrated process development activities
  • Assist with scaling workflows and implementing improved operational practices as the platform grows

Benefits

  • healthcare coverage
  • annual incentive program
  • retirement benefits
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