Senior Research Assistant
About The Position
The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. Memorial Sloan Kettering Cancer Center seeks a Senior Research Assistant to coordinate the laboratory biobank, including the reception and banking of specimens derived from clinical practice or from an array of clinical trials being held in MSKCC, as well as processing of the clinical specimens for downstream applications including the development of patient-derived xenograft (PDX) models, single cell RNA/ATAC/DNA/CITE sequencing, spatial transcriptomics and flow cytometry. This role involves coordinating with a multidisciplinary team involving different MSKCC core facilities, clinicians and research coordinators, and development and maintenance of reference databases. The Senior Research Assistant will also coordinate with the pathology core at MSKCC for the performance of histology work and employ novel technologies in the lab. Additionally, the position provides in-vivo experiment support, leads independent research projects related to lung cancer therapeutics, supervises, mentors, and trains new recruits, assists postdocs and Ph.D. students with molecular biology work, and acts as the safety manager of the laboratory.
Requirements
- Master’s degree or equivalent in Biology, Biochemistry, Biomedicine, or a directly related health science field and 3 years of experience in the job offered or working in medical research; or a Bachelor’s in these fields and 5 years of experience in the job offered or working in medical research
- 3 years of experience with simultaneous single nuclei RNA/ATACseq and DNAseq on flash frozen tissue samples
- 3 years of experience with leading research projects in lung cancer therapeutics as evidenced by publications in the field
- 1 year of experience with processing of clinical specimens and maintenance of the laboratory biobank
- 1 year of experience with training of lab members in molecular and cell biology techniques
- 1 year of experience with writing and renewing IACUC and IBC protocols
Responsibilities
- Coordinate the laboratory biobank, including the reception and banking of specimens derived from clinical practice or from an array of clinical trials being held in MSKCC
- Process clinical specimens for downstream applications including the development of patient-derived xenograft (PDX) models, single cell RNA/ATAC/DNA/CITE sequencing, spatial transcriptomics and flow cytometry
- Coordinate with a multidisciplinary team involving different MSKCC core facilities, clinicians and research coordinators
- Develop and maintain reference databases
- Coordinate with the pathology core at MSKCC for the performance of histology work (including embedding, sectioning, immunohistochemistry and review of tissue, and state-of-the art multiplexed imaging techniques)
- Employ novel technologies in the lab, including single cell nuclei sequencing of small biopsies and PDXs and simultaneous single nuclei RNA/ATACseq and single nuclei DNAseq on flash frozen tissue samples
- Provide in-vivo experiment support, including preparing cells for injection into mice, and processing collected specimens for preservation for downstream molecular analyses (RNAseq, ATACseq, ChIPseq and proteomics)
- Lead independent research projects related to lung cancer therapeutics
- Supervise, mentor, and train new recruits in molecular biology and cell culture techniques
- Assist postdocs and Ph.D. students with molecular biology work, including Western Blots, routine cell culture work, FACS sorting, flow cytometry, plasmid amplification, and PCR
- Act as the safety manager of the laboratory by coordinating with the institutional Environmental, Health and Safety and ensuring the lab is compliant with safety standards
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Number of Employees
1,001-5,000 employees
