Senior Principal Scientist, Bispecifics & Antibody Engineering

Regeneron Pharmaceuticals•Tarrytown, GA

4d•$150,500 - $245,500•Onsite

About The Position

Regeneron is seeking a Senior Principal Scientist to lead a small team within its Bispecific Antibodies group. The role uses structural insight to design, engineer, and optimize next-generation bispecific and multispecific antibody therapeutics. The scientist will integrate structural data with AI/ML-enabled design and high-throughput, automated experimental validation, and co-champion programs with biology leads from concept through IND. The position is onsite in Tarrytown, New York.

Requirements

Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field.
At least 8 years of post-Ph.D. experience, including at least 5 years in the biotech or pharmaceutical industry.
At least 2 years of direct people-management experience, with a record of successfully developing scientists.
Record of innovation and research accomplishments in antibody or protein therapeutic engineering, such as publications, patents, or programs advanced into development.
Experience engineering bispecific or multispecific antibody formats.
Deep hands-on expertise in molecular cloning, protein expression, purification, and biochemical or biophysical characterization.
Experience with mammalian cell culture and cell-based assay development.
Strong organization and flexibility to lead multiple projects in parallel.

Nice To Haves

Experience applying computational design and AI/ML tools to protein engineering.
Experience with automated or high-throughput protein engineering workflows.

Responsibilities

Set molecular design strategy for bispecific and multispecific antibodies based on target biology, structure, and mechanism of action.
Lead structure-guided design of novel formats, including binding-arm selection, epitope and geometry optimization, and chain pairing, using tools such as AlphaFold, Rosetta, MOE, and PyMOL.
Drive protein engineering campaigns that integrate AI/ML and in silico design into iterative design-build-test-learn cycles with computational partners.
Oversee high-throughput construct generation, expression, purification, biophysical characterization, and cell-based functional assays to rank molecules for activity and developability.
Build curated engineering datasets and design rules to strengthen the bispecific platform across oncology, immunology, and infectious disease.
Lead, mentor, and develop a team of scientists, partnering with internal and external groups to advance the pipeline.
Apply structural biology to solve antibody and protein engineering problems by combining experimental data with computational and AI/ML-driven design.
Lead multiple projects in parallel and communicate structural insights clearly to non-specialist audiences.
Co-champion programs with biology leads from concept through IND.

Benefits

Annual bonuses or other incentive plans may be offered, depending on country and role.
Equity awards may be offered, depending on country and role.
Pension or retirement benefits may be offered, depending on country and role.
401(k) company match may be offered, depending on country and role.
Health and wellness programs may be offered, depending on country and role.
Fitness centers may be available, depending on country and role.
Insurance benefits, including medical, dental, vision, life, and disability coverage, may be offered, depending on country and role.
Paid time off may be offered, depending on country and role.
Family support benefits may be offered, depending on country and role.
Competitive and comprehensive total rewards package.