Senior Medical Director, Oncology Clinical Development - Lung

GSK • Upper Providence, PA

3d • $242,550 - $404,250 • Hybrid

About The Position

The Senior Medical Director, Oncology Clinical Development - Lung is a senior physician leader within the clinical programme team, providing medical oversight, strategic clinical insight, and a patient-centred perspective across the design, conduct, and interpretation of clinical studies. The role ensures medical considerations, patient safety, and clinical integrity are consistently applied across studies within a programme.

Within the clinical strategy defined by the Clinical Development Lead (CDL), the Senior Medical Director partners with the Senior Scientist and cross-functional teams to integrate physician expertise into study execution and programme-level decisions. As a senior member of the Clinical Matrix Team (CMT), the role contributes to complex clinical decisions, regulatory interactions, and external scientific engagement. It also provides oversight and guidance to Medical Directors within the programme.

The role requires an on-site office presence of at least two days per week at a GSK site in Zug, Switzerland; Stevenage or London, UK; or Pennsylvania or Massachusetts, US. For candidates initially based at the Stevenage site, the position will temporarily be based there before a planned office relocation to Cambridge, UK, proposed to take effect by early 2029.

For candidates based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary range is $242,550–$404,250. The position also offers an annual bonus and eligibility for a share-based long-term incentive program, dependent on role level. Available benefits include health care and other insurance for employees and family, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. Compensation for countries without a posted salary range will be discussed during recruitment.

Requirements

• Medical degree and completion of advanced specialty training, fellowship, or country-equivalent higher-level qualification in oncology or haematology.
• Experience leading lung cancer drug development, including early-phase trials.
• Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes.
• Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies.
• Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks.
• Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions.

Nice To Haves

• Deep expertise in lung cancer, including experience leading or supporting clinical development programmes across early- and/or late-stage clinical studies.
• Strong scientific communication and stakeholder engagement skills, with the ability to influence internal and external audiences.
• Deep experience in oncology clinical development across multiple studies or programmes, including Phase I–III.
• Experience contributing to or leading aspects of regulatory interactions, such as IND, scientific advice, and NDA/MAA.
• Demonstrated experience engaging with KEEs, advisory boards, and oncology scientific communities.
• Track record of scientific publications and congress presentations.
• Deep understanding of oncology disease biology and the evolving treatment landscape across solid tumours and/or haematological malignancies.
• Experience mentoring or providing oversight to other physicians within a clinical development organisation.
• Experience contributing to clinical and technical diligence for business development opportunities.

Responsibilities

• Provide senior medical oversight and clinical insight across study design, conduct, and data interpretation.
• Guide medical monitoring and safety oversight across studies, supporting consistent clinical judgement, patient safety, protocol adherence, and regulatory and organisational standards.
• Interpret complex clinical and safety data to inform programme-level insights and decisions, including safety, efficacy, patient impact, and benefit–risk assessment.
• Guide safety-data interpretation with pharmacovigilance, including signal detection, escalation, and programme-wide benefit–risk evaluation.
• Participate in safety review forums such as SRT and IDMC, providing senior physician input on complex safety questions.
• Provide senior medical input into protocol development and study design, ensuring clinical relevance, feasibility, patient-centred design, and alignment with the CDL-defined clinical strategy.
• Guide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or multi-study programmes.
• Support resolution of complex medical questions arising during study conduct and ensure consistency of medical considerations across studies.
• Partner with the Senior Scientist and cross-functional teams to integrate medical considerations across study execution and programme delivery.
• Contribute to programme-level data interpretation and support CDL-led benefit–risk assessment and clinical positioning.
• Guide development of scientific communications, including publications, congress materials, and clinical summaries.
• Maintain understanding of disease biology, evolving treatment paradigms, and the competitive landscape to inform clinical interpretation and programme strategy.
• Contribute senior medical expertise to regulatory interactions and Health Authority discussions, including responses to complex clinical and safety queries.
• Represent the programme at advisory boards, steering committees, and external scientific forums; engage with investigators, KEEs, and scientific collaborators.
• Lead or contribute to clinical and technical diligence assessments of business development opportunities.
• Serve as a senior CMT member, influencing cross-functional alignment and study- and programme-level decision-making.
• Contribute medical expertise to disease-area strategy, integrated evidence planning, and Medical Affairs discussions.
• Lead or contribute to Oncology Clinical Development-wide initiatives and workstreams.
• Provide oversight, guidance, and mentorship to programme Medical Directors, supporting consistent, high-quality medical input across studies.
• Support clinical capability development through coaching on medical monitoring, data interpretation, and external engagement; contribute to talent development, performance discussions, and capability building.

Benefits

• Annual bonus
• Eligibility to participate in a share-based long-term incentive program, dependent on role level
• Health care and other insurance benefits for employee and family
• Retirement benefits
• Paid holidays
• Vacation
• Paid caregiver/parental and medical leave

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree