Senior Mass Spectrometry Scientist

Molecular You Co•Vancouver, BC

4d•Hybrid

About The Position

Molecular You is redefining what it means to know your health. Our precision multi-omic platform generates deep molecular profiles that help people and their clinicians take meaningful, proactive action. As a Senior Mass Spectrometry Scientist, you will be a technical cornerstone of our analytical laboratory—developing, validating, performing, and overseeing clinical multi-omic assays that underpin the absolute quantification workflows at the heart of our clinical operations. This is a high-impact opportunity for a scientist who combines deep technical expertise with the discipline of a regulated clinical environment and is energized by translating rigorous analytical science into real-world health impact. You will own assay development from conception through ISO-compliant deployment, solve complex instrumentation and shape next-generation MS capabilities, and mentor junior scientists in best practices.

Requirements

PhD. in Analytical Chemistry, Biochemistry, Proteomics, Metabolomics, or a closely related field; or M.Sc. with 5+ years of directly relevant industry experience.
5+ years of hands-on experience developing and validating quantitative MRM-MS assays in a professional laboratory setting.
Demonstrated expertise in absolute quantification by LC-MS/MS using stable isotope-labeled internal standards and external calibration curves.
Deep familiarity with at least one major LC-MS/MS vendor platform (Agilent, Sciex, Thermo Scientific, or Waters).
Expertise in operating LC-MS/MS systems and using associated acquisition, processing, and method-development software.
Proven ability to independently troubleshoot complex analytical problems across chromatography, ionization, and detection.
Experience working with a laboratory information management system (LIMS).

Nice To Haves

Experience in a multi-omic or systems biology context, with exposure to proteomics, metabolomics, or lipidomics at a clinical or translational scale.
Experience with clinical laboratory setup, launch, or scale-up.
Familiarity with Skyline or similar open-source MRM data management and analysis tools.
Direct experience working in or supporting an ISO 15189-accredited or equivalent clinical or regulated analytical laboratory. Prior involvement in ISO accreditation drives, external laboratory audits, or regulatory submissions
Experience with automated sample preparation platforms (e.g., Hamilton, Tecan) and their integration with MS workflows.
Comfort working in a fast-paced, cross-functional environment where scientific rigor and operational agility are equally valued.
A builder mindset: you enjoy creating robust analytical systems, improving how a laboratory operates, and collaborating across disciplines to turn complex science into scalable clinical impact.

Responsibilities

Develop, optimize, and implement proprietary MRM-MS assays for targeted absolute quantification of proteins, lipids, metabolites, and other analytes across complex biological matrices (including plasma, serum, and potentially others).
Execute full method validation packages in accordance with FDA Bioanalytical Method Validation guidance, CLIA and ISO 15189 frameworks.
Develop, update, and maintain SOPs that support robust, reproducible, and audit-ready laboratory workflows.
Develop technical and training transfer packages that enable partner laboratories to accurately and reproducibly run our assays in a clinical laboratory environment.
Develop new MS-based technologies for integration into Molecular You's clinical multi-omic assay workflow.
Serve as a subject matter expert for LC-MS/MS platforms (e.g., Agilent, Sciex, Thermo, Waters), including source optimization, ion-pair selection, chromatographic troubleshooting, and scheduled MRM configuration.
Lead systematic troubleshooting of assay failures, matrix interference, ion suppression, and carryover issues, escalating findings and implementing permanent corrective actions.
Maintain instrument qualification (IQ/OQ/PQ) records and coordinate preventative maintenance schedules with vendors in accordance with laboratory SOPs.
Operate within a regulated clinical laboratory (ISO 15189 or equivalent) environment, maintaining strict adherence to SOPs, chain-of-custody protocols, and sample integrity requirements.
Partner with the laboratory director and QA/QC team to prepare, maintain, and execute documentation required for ISO accreditation, proficiency testing, and external audits.
Ensure all assay workflows are audit-ready, including instrument logs, reagent traceability, QC charts, and deviation records.
Perform and review quantitative data analysis using software platforms such as MassHunter, Skyline, or equivalent, ensuring accurate peak integration and batch review.
Author high-quality technical reports, SOPs, and method transfer documents; present findings to cross-functional stakeholders including bioinformatics, product, and medical teams.
Contribute to peer-reviewed publications and support intellectual property activities as applicable.
Mentor and coach junior scientists and laboratory technicians in MRM-MS principles, laboratory operations, and quantitative method development.
Collaborate with bioinformaticians, data scientists, and software engineers to integrate MS data streams into Molecular You's broader multi-omic platform.
Support procurement and capital equipment decisions for next-generation mass spectrometry infrastructure.