Senior Manager, Supply Chain

Parabilis Medicines•Cambridge, MA

7d•Onsite

About The Position

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and AR ON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

Requirements

Bachelor’s degree in Supply Chain, Life Sciences, or related field (Master’s preferred)
Minimum 5 years of global clinical supply chain experience within biotech, pharma, or medical device
Hands-on experience with IRT/IXRS systems (e.g., 4G Clinical, Almac, Endpoint)
Experience supporting global Phase I–III clinical trials (commercial launch experience preferred)
Proficiency with Microsoft Office and inventory/ERP systems
Strong understanding of GxP, GDP, and ICH-GCP regulations
Proven ability to manage complex global supply operations and mitigate risk
Strong analytical, organizational, and problem-solving skills
Effective cross-functional collaboration and communication across internal teams and external partners
Able to work on-site and attend in-person meetings

Nice To Haves

Experience drafting SOPs, Pharmacy Manuals, and clinical supply documentation preferred
Familiarity with cold chain and temperature-controlled distribution preferred
APICS/CSCP or PMP certification a plus
Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus

Responsibilities

Lead the end-to-end operational management of investigational product (IP) and clinical trial materials across global Phase I–III studies.
Ensure timely, compliant, and efficient delivery of clinical supplies, while partnering cross-functionally with Clinical Operations, Quality, Regulatory, CMC, and external vendors to support study execution.
Develop and maintain study-level supply plans and forecasts aligned with enrollment, protocol design, and site activation timelines.
Coordinate packaging, labeling, release, and global distribution of investigational products and ancillary materials.
Oversee inventory across depots and study sites, proactively mitigating risks to avoid shortages or excess.
Serve as business owner of the IRT system, including setup, configuration, validation, and ongoing management.
Partner cross-functionally to align supply strategy with clinical and regulatory requirements and ensure seamless execution.
Author and maintain supply-related documentation, including SOPs, Pharmacy Manuals, and study-specific materials.
Ensure compliance with GxP, GDP, and ICH-GCP standards, supporting audits and inspection readiness.
Manage global logistics, vendor oversight, and third-party partners to ensure uninterrupted supply across regions.