Senior Manager, Sample Management

Revolution Medicines•Redwood City, CA

23h•Onsite

About The Position

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

Requirements

BS/MS or equivalent degree in chemistry, biology, engineering, or a related scientific discipline.
5-10 years experience in sample management, compound management, or laboratory operations.
Proven experience directly supervising and leading technical staff in a laboratory environment.
Hands-on experience with automated sample storage systems, LIMS, and laboratory automation tools.
Strong attention to detail, operational discipline, and commitment to data integrity.
A proven background in continuous improvement methodologies.
Comfort operating in a fast-paced, collaborative discovery environment.
Clear and effective written and verbal communication skills.

Nice To Haves

Experience supporting small-molecule drug discovery programs.
Experience training and mentoring early-career scientists or technicians.
Exposure to process improvement initiatives or system implementations.
Familiarity with vendor-managed laboratory automation platforms.
Direct experience with Cenevo’s Sample Management Software Mosaic.

Responsibilities

Provide direct, hands-on leadership to sample management staff, including daily work assignment, prioritization, and real-time problem solving.
Lead and participate in core sample management activities, including sample receipt, storage, tracking, retrieval, and disposal.
Ensure smooth day-to-day operation of automated storage systems, LIMS, and supporting laboratory infrastructure.
Train, mentor, and develop staff through on-the-job coaching, feedback, and performance management.
Develop, maintain, and enforce SOPs and best practices for all critical sample management processes.
Identify and implement process improvements to enhance efficiency, reliability, and scalability.
Serve as the primary point of contact for cross-functional partners, ensuring timely and accurate delivery of materials.
Work closely with the Director of Sample Management to communicate capacity, risks, and resource needs.
Support onboarding and ramp-up of new staff and technologies within the laboratory.
Provide technical leadership and subject matter expertise in tissue culture, including aseptic technique, routine cell line maintenance, culture optimization, cryopreservation, thawing, and recovery.
Lead the design and execution of fit-for-purpose cell banking strategies, including the creation, expansion, characterization, qualification, release, use, and retirement of research, master, and working cell banks.
Plan and oversee cell bank expansion activities, including seed-train design, passage management, scale-up scheduling, resource allocation, and assessment of growth, viability, and recovery performance.
Establish and maintain cell bank inventory controls that ensure unique identification, accurate storage locations, complete metadata, chain of custody, inventory reconciliation, capacity planning, and full lifecycle traceability.
Define and enforce contamination-control practices for tissue culture operations, including segregation strategies, biosafety requirements, cleaning and disinfection procedures, and appropriate response to contamination events.
Oversee cell bank quality assessments, including cell identity or authentication, sterility, mycoplasma status, viability, morphology, purity, and other program-specific acceptance criteria.
Provide expert troubleshooting for tissue culture and cell banking issues, investigate deviations and performance trends, determine root cause, and implement effective corrective and preventive actions.
Ensure cell culture and cryogenic equipment, including biological safety cabinets, incubators, controlled-rate freezers, and liquid nitrogen storage systems, is appropriately qualified, monitored, maintained, and fit for intended use.
Partner with research teams to forecast cell line demand, prioritize banking and expansion work, establish service levels, and deliver qualified cell stocks that meet program timelines.
Lead technical transfer, method standardization, and training for tissue culture and cell banking processes, including oversight of external vendors or contract laboratories when applicable.