Global Commercial Strategy (GCS): Senior Manager, Early GI, Rheumatology, and Neurology

Pfizer • New York City, NY

1d • Hybrid

About The Position

The Senior Manager, Early Commercial Rheumatology, GI, and Neurology is a key role within the Inflammation & Immunology (I&I) Early Commercial Business, part of the Global Commercial Strategy organization, reporting to the I&I Disease Area Lead. This role will include contributing to long-range commercial strategy, disease-area portfolio prioritization, early commercial assessments, and investment decision support across Rheumatology, GI, and Neurology priorities within the I&I portfolio. The broader I&I and Rare Disease portfolio represents significant strategic value to realizing Pfizer's vision to achieve leadership via breakthroughs in prioritized diseases and biological axes, with the goal of generating highly differentiated, multi-indication mega-blockbusters. Today, the portfolio delivers more than $10B globally, with 22 ongoing clinical studies underway to significantly expand the product portfolio over the next several years. This role will help translate that ambition into clear disease-area strategies, disciplined portfolio choices, and integrated commercial plans that maximize patient impact and enterprise value. This leader will serve as the asset-level commercial voice for a subset of the assigned disease areas, bringing scientific depth, commercial judgment, and enterprise perspective to shape early development choices, product concepts, external innovation opportunities, and future value creation. The Senior Director will partner closely with R&D, Medical Affairs, Global Access Strategy & Pricing (GASP), Business Analytics & Insights, Competitive Intelligence, Business Development, and US and International Commercial teams to translate scientific, clinical, market, access, and competitive insights into clear portfolio recommendations and actionable strategic choices. This role requires a commercial strategist who can operate across ambiguity, influence senior cross-functional stakeholders, and advance disciplined trade-off decisions, long-range portfolio thinking, and AI-enabled ways of working in support of patient impact and enterprise value realization.

Requirements

• Bachelor's degree required; MBA or advanced degree preferred.
• 6+ years with a BA/BS, 5+ years with MBA/MS, 1+ years with PhD or JD of experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, market research, forecasting, analytics, or related field.
• Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations.
• Experience leading early commercial assessment, business case development, opportunity assessment, or cross-functional strategic planning.
• Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision-making.
• Strong communication, executive presence, problem-solving, and stakeholder management skills.
• Advanced degree in business, life sciences, public health, medicine, pharmacy, or related field preferred.
• Experience in Rheumatology, GI, Neurology, I&I, specialty care, or other complex therapeutic areas preferred.
• Experience with commercial development, early asset strategy, portfolio management, Business Development assessments, forecasting, valuation, or investment prioritization.
• Demonstrated ability to develop long-term strategies for products or disease areas and secure alignment from senior leadership.
• Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization.
• Track record of leading cross-functional teams, influencing without authority, and making recommendations with incomplete information.
• Comfort working in an AI-native or AI-augmented environment; experience using AI tools to support strategy, synthesis, or analysis is a plus.
• Ability to thrive in ambiguity, operate with enterprise mindset, and adapt to evolving portfolio priorities.
• Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.
• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
• Permanent work authorization in the United States.

Responsibilities

• Support development of long-range commercial and portfolio strategy across a subset of Rheumatology, GI, and Neurology disease areas, spanning early pipeline assets, lifecycle opportunities, external innovation, and emerging disease-area opportunities.
• Support generation of integrated near-, mid-, and long-term views of disease-area opportunities, risks, and investment priorities to inform portfolio decision-making.
• Synthesize scientific, clinical, commercial, access, competitive, and patient insights to identify priority opportunities and strategic trade-offs.
• Monitor shifts in the scientific and competitive landscape to identify emerging trends, market discontinuities, and implications for future I&I strategy.
• Translate disease-area strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross-functional portfolio discussions.
• Provide commercial leadership for portfolio prioritization, investment choices, and development opportunities across assigned disease areas.
• Pressure-test commercial assumptions, value drivers, risks, uncertainties, and evidence needs that may influence future launch potential, lifecycle value, and portfolio performance.
• Lead development of executive-ready materials that communicate strategic rationale, opportunity attractiveness, trade-offs, and recommended actions.
• Partner with cross-functional leaders to align on key choices related to indication sequencing, evidence generation, market development, and lifecycle opportunities.
• Support disciplined decision-making by ensuring assigned disease-area recommendations are grounded in patient need, scientific opportunity, market potential, access dynamics, and enterprise value.
• Lead early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and potential future product concepts across assigned areas.
• Develop and refine product concepts, target product profiles, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions.
• Ensure unmet need, standard of care, competitive dynamics, patient/HCP insights, and access considerations are translated into differentiated commercial hypotheses.
• Provide commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions in partnership with cross-functional colleagues.
• Build repeatable approaches for high-quality early commercial strategy outputs across the team.
• Lead commercial strategy input for external innovation and Business Development opportunities relevant to assigned disease areas.
• Guide assessment of strategic fit, market potential, valuation inputs, competitive scenarios, and portfolio implications for potential external opportunities.
• Partner with Business Development, R&D, GASP, BAI, and Competitive Intelligence colleagues to pressure-test assumptions and identify key decision points.
• Represent the commercial perspective in internal discussions related to external opportunities and broader disease-area strategy as needed.
• Influence without direct authority by aligning stakeholders around shared insights, strategic choices, and implications for the I&I portfolio.
• Build trusted working relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, and Commercial Regions.
• Foster a culture of enterprise thinking, scientific curiosity, accountability, collaboration, and talent development within the team.
• Set expectations for responsible, AI-enabled ways of working across the team to improve speed, quality, consistency, and scalability of portfolio strategy outputs.
• Champion use of AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, and decision-support efficiency.
• Identify opportunities to embed AI into repeatable workflows, templates, portfolio reviews, and strategic decision-support processes.
• Use performance insights, stakeholder feedback, and team learnings to continuously improve AI-enabled ways of working across assigned disease areas.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• paid vacation, holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior