Senior Manager, Business Assessment - Vaccines

Pfizer • New York City, NY

7d • Hybrid

About The Position

The Business Assessment (BA) team is responsible for generating investment cases for pipeline and business development decisions. BA's assessments are independent and rigorous, applying the same standards whether supporting or challenging investment cases. Situated within Pfizer's Global Commercial Analytics (GCA) organization, BA is a center of analytical excellence that unifies revenue forecasting and elevates strategic contributions across the asset lifecycle. The team is recognized for its thought leadership, epi-forecasting expertise, innovative analytical capabilities, and clear communication of complex information. The Senior Manager will independently manage commercial assessments and forecasts from model building to assumption defense, informing investment decisions and partnering with cross-functional teams. This role requires hands-on modeling and strategic input into trade-off decisions, ensuring consistency in assessment approaches. The Senior Manager will present analysis and recommendations to executive governance bodies. The role is primarily focused on vaccines, with unique forecasting mechanics, but will also cover other therapeutic areas, emerging platforms, and novel modalities, offering broad portfolio exposure.

Requirements

• 6+ years (Bachelor’s degree) or 5+ years (Master’s degree) of relevant experience in the biopharmaceutical industry, life sciences consulting, or a comparable analytical function.
• Advanced Excel proficiency — demonstrated ability to build, audit, and document multi-tab forecast and valuation models.
• Strong PowerPoint skills for executive-level materials.
• Demonstrated hands-on experience building or owning quantitative commercial forecast and valuation models, including patient-flow/epidemiology-based demand builds, uptake curves, gross-to-net pricing, probability-of-success risk adjustment, and NPV or rNPV valuation.
• Experience using epidemiology literature, analyst reports, secondary/claims data, primary research, and pricing and market access inputs as the basis for a quantitative forecast.
• Experience presenting analysis and recommendations directly to senior executive audiences, including engaging commercial and research leaders.
• Permanent work authorization in the United States.

Nice To Haves

• Prior experience in biopharma forecasting, life sciences consulting, financial services or other analytical professions.
• MBA or life sciences advanced degree.
• Experience in the business development process, specifically in opportunity identification, commercial assessment, and deal structure.
• Vaccines forecasting experience, including recommendation-driven uptake (e.g., ACIP or equivalent), public versus private channel dynamics, publicly funded programs such as VFC, cohort-based epidemiology, seasonality, and tender or multilateral markets.
• Demonstrated use of AI/LLM tooling within an analytical workflow — evidence synthesis, model QC, code-assisted analysis — with assumptions kept traceable and auditable.
• A track record of delivering an unfavorable or contrarian assessment that held up under senior scrutiny.
• Proficiency in Python, R, or SQL for data handling, automation, and scenario analysis.
• Experience influencing without direct authority in a matrixed organization, and supporting or leading cross-functional teams under compressed timelines with incomplete information.
• Working knowledge of healthcare and pharmaceutical industry trends, competitor strategies, dynamics in the US and other major global markets, and the drug development process.
• Demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Responsibilities

• Build and own assessments of pipeline and BD opportunities, including epidemiology-based patient flow, treatment exposure, uptake and diffusion curves, gross-to-net price build, and risk-adjusted NPV.
• Collaborate with cross-functional partners to ensure analysis is rigorous, transparent, and based on common and well-supported modeling techniques and assumptions.
• Take and defend an independent position, including recommending against an opportunity when analysis does not support it, even with incomplete information under tight timelines.
• Gather input from key internal expert stakeholders on clinical development plans, commercial profiles, and commercial evaluations.
• Serve as commercial lead or co-lead of BD commercial subteams, owning the integrated workplan, framing the commercial narrative, driving cross-functional alignment, and delivering decision-ready recommendations.
• Integrate in-line and BD/pipeline forecasts, connecting assessments to in-line assumptions, cannibalization logic, and Long-Range Forecast (LRF) revenue projections.
• Utilize AI tooling as a standard part of the workflow for evidence synthesis, competitive landscaping, model QC, code-assisted analysis, and drafting executive materials.
• Scope and commission qualitative and quantitative primary market research with physicians, key opinion leaders, and patients, managing consulting and vendor resources.
• Develop analytically supported recommendations to facilitate investment trade-off decisions across therapeutic areas and BD opportunities.
• Determine the appropriate level of rigor and external insights/research required based on timeline and decision.
• Work flexibly and comfortably on multiple therapeutic areas in a matrixed team.
• Support additional category and Pfizer portfolio-level projects, such as category strategy, knowledge management, best practice synchronization, and professional development.
• Support enterprise-level initiatives and evaluations using internal forecasts, analyst reports, and other secondary data.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• Paid vacation, holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior