Senior IT Systems Administrator

Cabaletta Bio Inc.•Philadelphia, PA

10h•Hybrid

About The Position

Reporting to the Director of IT and Data Sciences, we are seeking a Senior IT Systems Administrator to support the implementation, operation, and continuous improvement of Cabaletta’s IT infrastructure and collaboration systems. This individual will work across departments to ensure systems are reliable, secure, and aligned with business needs. This is a hands-on role requiring strong experience with Microsoft 365, AWS hybrid cloud environments, and Linux/Windows systems. The role also involves close collaboration with internal stakeholders and external service providers to support consistent, high-quality IT service delivery. This role is located in Center City, Philadelphia. We operate in a hybrid work environment, with an expectation of 2+ days per week in the office as needed.

Requirements

Bachelor’s degree with 5+ years of experience as a Systems Administrator or similar role in biotech, pharmaceutical, or life sciences industries
Experience with LAN/WAN networks, including wireless and firewall management
Strong experience with AWS services, including EC2, VPC, Elastic Load Balancing (ALB/NLB), RDS, and S3
Strong experience with Windows Server (2016/2019/2022) and RHEL (7/8/9)
Experience supporting Microsoft 365 applications, including Exchange, SharePoint, Teams, and Entra ID (SSO, SAML, OIDC)
Solid understanding of Active Directory, Group Policy, and file system permissions
Experience with backup and recovery platforms
Experience supporting cybersecurity practices in a regulated environment, including patch management, access controls, and endpoint security
Familiarity with firewalls, network security concepts, and identity management
Strong curiosity and ability to learn quickly in a fast-paced environment
Strong client support orientation and ability to work with users across varying technical skill levels
Comfortable operating in a growing, dynamic organization

Nice To Haves

Experience supporting segmented or regulated network environments is a plus
Exposure to security monitoring tools (e.g., SIEM, endpoint detection and response) is a plus
Experience working with external service providers or managed services environments is preferred
Excellent problem-solving, communication, and organizational skills

Responsibilities

Own and contribute to the design, implementation, configuration, and support of servers, network devices, and firewalls in collaboration with IT and business teams
Own the operational health of IT systems, including end-user support, break-fix activities, monitoring, patch management, system backup/recovery, system administration, troubleshooting, and issue resolution
Lead and coordinate Tier 2/3 escalations, working with internal stakeholders and external partners to ensure timely resolution
Act as a primary technical point of contact for external service providers, helping to ensure alignment with Cabaletta’s operational and security expectations
Partner with external support providers to support consistent service delivery, including responsiveness, quality of work, and adherence to defined service expectations
Participate in the review of escalations, recurring issues, and incident trends to identify opportunities for improvement and reduce operational risk
Support coordination and communication of infrastructure and system changes to ensure appropriate documentation, awareness, and alignment with internal processes
Collaborate with internal stakeholders and service providers to prioritize work and support a high-quality end-user experience
Contribute to continuous improvement of IT service delivery processes and operational practices
Administer and support core Linux and Microsoft technologies across cloud and hybrid environments
Maintain and support AWS hybrid cloud environments, including EC2, VPC, Elastic Load Balancing (ALB/NLB), RDS, and S3
Maintain and support Microsoft 365 systems, including Exchange, SharePoint, Teams, and Entra ID
Support the implementation and maintenance of cybersecurity controls across infrastructure and cloud environments, including identity, access, and endpoint protections
Support identity and access management practices, including role-based access and least privilege principles
Assist in monitoring, responding to, and remediating security events in coordination with internal teams and external partners
Contribute to vulnerability management activities, including patching, system hardening, and periodic security reviews
Maintain business continuity and disaster recovery systems, including periodic testing to meet data retention and compliance requirements
Ensure IT systems maintain compliance with cybersecurity and regulatory standards, including participation in audits, risk assessments, and remediation activities
Create and maintain comprehensive documentation of IT systems (e.g., SOPs, user guides, training materials, test plans, validation documents)
Support lifecycle management of IT systems across on-premise and cloud platforms
Collaborate with QA/CSV teams to support validation processes, including development and execution of test scripts
Support data integrity processes for IT systems and laboratory environments
Support staff and partners in effectively using technology; provide training as required
Other assignments and projects as required