Senior Downstream Process Engineer, Commercial - BPG

Thermo Fisher Scientific•Waltham, MA

5d•Remote

About The Position

Thermo Fisher Scientific’s Bioproduction Group (BPG) is seeking a Senior Downstream Process Engineer (Commercial) to serve as a technical leader supporting the design and development of downstream bioprocess solutions for capital projects. This role focuses on harvest, clarification, filtration, and purification (including chromatography systems) supporting drug substance manufacturing. As a key member of the commercial organization, you will lead front-end engineering and proposal development (FEL/FEED) for customer capital investments, including greenfield and brownfield facility expansions. You will translate customer process requirements into technically robust, scalable, and commercially viable downstream solutions, while driving Thermo Fisher’s Bioproduction portfolio positioning. This is a highly visible, customer-facing role working with leading biopharma companies, CDMOs, biotech firms, and engineering partners (A&E, EPCM).

Requirements

Bachelor’s degree in Chemical Engineering, Biochemical Engineering, or related technical field required; Master’s or PhD preferred
8+ years of experience in downstream process engineering, purification, or bioprocess system design within the biopharma or life sciences industry
Strong expertise in downstream processing, including harvest/clarification, depth filtration, tangential flow filtration (TFF), and chromatography (e.g., protein A, ion exchange)
Experience with capital equipment projects and development of complex engineering proposals
Demonstrated experience in front-end engineering, process scale-up, and purification process design
Familiarity with single-use technologies and automation systems (PLC/SCADA, DeltaV) preferred
Strong understanding of cGMP and global regulatory requirements (FDA, EMA, ICH)
Proven ability to collaborate across cross-functional and global teams
Excellent communication and presentation skills, with experience engaging technical and executive stakeholders
Ability to manage multiple priorities in a fast-paced, customer-driven environment

Nice To Haves

Familiarity with single-use technologies and automation systems (PLC/SCADA, DeltaV) preferred

Responsibilities

Lead downstream process design, including PFDs, P&IDs, balances, and equipment specs
Develop scalable solutions for harvest, clarification, depth filtration, TFF, and chromatography purification systems
Ensure compliance with cGMP and global regulatory standards
Lead FEL/FEED efforts, translating customer needs into defined scopes
Develop costed proposals with scope, assumptions, risks, and exclusions
Support CAPEX estimates aligned with commercial and margin goals
Serve as primary technical contact for customers and project teams
Lead design reviews, technical discussions, and executive presentations
Collaborate cross-functionally across sales, engineering, and global teams
Contribute to technical marketing (white papers, webinars, presentations)
Represent Thermo Fisher at industry events to promote bioproduction solutions
Ensure smooth handoff to execution teams with clear scope and continuity
Provide technical guidance during early project phases as needed

Benefits

Competitive remuneration
Annual incentive plan bonus scheme
Healthcare
Company 401k
A range of employee benefits
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO)
10 paid holidays annually
Paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave)
Accident and life insurance
Short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount