Senior Downstream Process Engineer, Commercial - BPG
About The Position
Thermo Fisher Scientific’s Bioproduction Group (BPG) is seeking a Senior Downstream Process Engineer (Commercial) to serve as a technical leader supporting the design and development of downstream bioprocess solutions for capital projects. This role focuses on harvest, clarification, filtration, and purification (including chromatography systems) supporting drug substance manufacturing. As a key member of the commercial organization, you will lead front-end engineering and proposal development (FEL/FEED) for customer capital investments, including greenfield and brownfield facility expansions. You will translate customer process requirements into technically robust, scalable, and commercially viable downstream solutions, while driving Thermo Fisher’s Bioproduction portfolio positioning. This is a highly visible, customer-facing role working with leading biopharma companies, CDMOs, biotech firms, and engineering partners (A&E, EPCM).
Requirements
- Bachelor’s degree in Chemical Engineering, Biochemical Engineering, or related technical field required
- 8+ years of experience in downstream process engineering, purification, or bioprocess system design within the biopharma or life sciences industry
- Strong expertise in downstream processing, including harvest/clarification, depth filtration, tangential flow filtration (TFF), and chromatography (e.g., protein A, ion exchange)
- Experience with capital equipment projects and development of complex engineering proposals
- Demonstrated experience in front-end engineering, process scale-up, and purification process design
- Strong understanding of cGMP and global regulatory requirements (FDA, EMA, ICH)
- Proven ability to collaborate across cross-functional and global teams
- Excellent communication and presentation skills, with experience engaging technical and executive stakeholders
- Ability to manage multiple priorities in a fast-paced, customer-driven environment
Nice To Haves
- Master’s or PhD preferred
- Familiarity with single-use technologies and automation systems (PLC/SCADA, DeltaV) preferred
Responsibilities
- Lead downstream process design, including PFDs, P&IDs, balances, and equipment specs
- Develop scalable solutions for harvest, clarification, depth filtration, TFF, and chromatography purification systems
- Ensure compliance with cGMP and global regulatory standards
- Lead FEL/FEED efforts, translating customer needs into defined scopes
- Develop costed proposals with scope, assumptions, risks, and exclusions
- Support CAPEX estimates aligned with commercial and margin goals
- Serve as primary technical contact for customers and project teams
- Lead design reviews, technical discussions, and executive presentations
- Collaborate cross-functionally across sales, engineering, and global teams
- Contribute to technical marketing (white papers, webinars, presentations)
- Represent Thermo Fisher at industry events to promote bioproduction solutions
- Ensure smooth handoff to execution teams with clear scope and continuity
- Provide technical guidance during early project phases as needed
Benefits
- Competitive remuneration
- Annual incentive plan bonus scheme
- Healthcare
- Company 401k
- A choice of national medical and dental plans, and a national vision plan, including health incentive programs
- Employee assistance and family support programs, including commuter benefits and tuition reimbursement
- At least 120 hours paid time off (PTO)
- 10 paid holidays annually
- Paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave)
- Accident and life insurance
- Short- and long-term disability
- Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
- Employees’ Stock Purchase Plan (ESPP)
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What This Job Offers
Job Type
Full-time
Career Level
Senior
