Senior Director, Real World Evidence Generation

Dompé•San Mateo, CA

2d•$285,000 - $370,000•Onsite

About The Position

The Senior Director, Real World Evidence (RWE) leads the strategic design and execution of real-world data and evidence generation initiatives that support clinical value, market access, and lifecycle management goals. This individual is accountable for building a robust, compliant RWE agenda within the Evidence Generation team that complements clinical trial evidence across indications. The Senior Director partners closely with R&D, Market Access, and the Global Medical Leads to ensure evidence generation is scientifically rigorous and strategically relevant, and manages a team of RWE scientists responsible for translating real-world data into decision-ready insights.

Requirements

PhD, PharmD, or equivalent in epidemiology, health outcomes, biostatistics, or related field
10+ years of experience in real-world evidence, epidemiology, or outcomes research
Demonstrated experience designing and executing observational research
Strong understanding of real-world data sources (claims, EHR, registries)
Experience presenting evidence to internal and external stakeholders

Nice To Haves

Experience in ophthalmology, immunology, or specialty care therapeutic areas
Publication record in peer-reviewed real-world evidence studies
Experience building an RWE function within a growing Medical Affairs organization

Responsibilities

Co-Own the Integrated Evidence Generation Plan (iEGP) across all Dompé indications — NAION, NK/PCED, AKC, oGVHD, and neurology pipeline — ensuring evidence priorities are strategically sequenced to support regulatory, payer, and scientific exchange goals
Partner with Global Medical Leads to translate indication-specific medical strategy into evidence priorities, identifying gaps between current data and the evidence needed for launch readiness, label expansion, or lifecycle management
Represent Evidence Generation in cross-functional governance forums including the Integrated Evidence Plan review, and serve as the senior MA voice in discussions with Clinical Development on trial-adjacent evidence needs
Maintain a forward-looking view of the competitive evidence landscape across indications, ensuring Dompé's evidence plan addresses emerging gaps or challenges
Provide strategic direction and senior oversight to the Associate Director of RWE & Epidemiology, ensuring the real-world evidence and epidemiology program is aligned to the iEGP and addresses payer, regulatory, and scientific exchange needs
Partner with Market Access and Commercial on the evidence requirements for HTA submissions and payer-facing evidence packages, ensuring the RWE and epidemiology program produces outputs that are credible, timely, and decision-grade
Represent RWE and epidemiology evidence in cross-functional medical strategy discussions, ensuring real-world data complements and contextualizes clinical trial data in the scientific narrative
Partner with R&D, Market Access, and Global Medical Leads to align evidence with payer and clinical needs
Support translation of RWE findings into publications, dossiers, and internal strategic recommendations
Manage relationships with external research partners, academic collaborators, and data vendors
Build, mentor, and manage a team of RWE scientists and associate directors
Manage RWE budget and prioritization across therapeutic areas
Establish study prioritization criteria in partnership with senior Medical Affairs leadership