Associate Director, Real-World Evidence & Epidemiology

Natera

7d • $176,000 - $220,000 • Remote

About The Position

We are seeking a Principal Clinical Scientist / Associate Director of Real-World Evidence & Epidemiology to drive observational evidence strategy for our Early Cancer Detection (ECD) portfolio. Population-scale liquid biopsy screening requires robust real-world evidence demonstrating clinical utility, clinical decision-making impact, and downstream patient outcomes. This ownership role uses real-world datasets to accelerate standard-of-care implementation across oncology diagnostics. Working with a builder mindset, you will partner across Clinical Science, Medical Affairs, Market Access, and Data Science to convert population-scale observational data into actionable clinical implementation strategies.

Requirements

• Advanced degree (PhD, MPH, MS, PharmD, or equivalent scientific credential) in epidemiology, health outcomes research, biostatistics, or a highly quantitative field
• 7+ years of experience leading real-world evidence generation, observational clinical research, or HEOR portfolios within the life sciences industry
• Documented experience executing observational studies across the entire asset lifecycle, from initial protocol drafting through statistical analysis and publication
• Deep data competency across real-world data sources, including longitudinal medical claims, electronic health records (EHR), and clinical registries

Nice To Haves

• Direct experience in oncology clinical trials, molecular diagnostics, or early cancer detection programs is preferred

Responsibilities

• Lead the design, protocol development, and execution of prospective observational studies, registries, and retrospective database assessments across early cancer detection programs
• Shape post-market evidence generation strategies by isolating critical clinical utility and implementation hurdles that can be resolved via real-world data assets
• Translate clinical and market requirements into rigorous, practical study designs, specifying target populations, clinical endpoints, and analytic frameworks
• Systematically identify and mitigate sources of bias, confounding factors, and missing data variance inherent in real-world healthcare datasets
• Design protocols evaluating clinical utility across diverse populations, ensuring the data generated directly supports precision interventions for individual patients and families
• Partner across Clinical Science, Medical Affairs, Product Management, and Market Access to prioritize evidence generation initiatives based on regulatory and clinical urgency
• Collaborate with Biostatistics and Data Science to engineer statistical analysis plans, interpret data findings, and deliver clinical contextualization
• Extract empirical evidence from early commercial and Laboratory Developed Test (LDT) cohorts to isolate adoption variables, diagnostic compliance, and real-world clinical workflows
• Deliver real-world data assets that dismantle payer coverage barriers and ground product positioning strictly in clinical utility metrics
• Convert complex epidemiological findings into clear, high-integrity scientific narratives for internal product governance and external healthcare stakeholders
• Spearhead the development of peer-reviewed abstracts, posters, presentations, and core manuscripts for major oncology and diagnostic conferences
• Engage with external clinical collaborators, investigators, and key opinion leaders (KOLs) to advance the platform base for early cancer detection

Benefits

• comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
• free testing for employees and their immediate families
• fertility care benefits
• pregnancy and baby bonding leave
• 401k benefits
• commuter benefits
• generous employee referral program

What This Job Offers

• Job Type: Full-time
• Career Level: Senior