Senior Director, Portfolio Integration Lead

GSK • Upper Providence, PA

19h • Hybrid

About The Position

The Portfolio Integration Lead (PIL) is a senior role in Oncology Clinical Development, responsible for shaping the advancement of multiple oncology programmes from our portfolio with a focus on particular cancers. Working closely with both the VP and Clinical Development Leads (CDLs) and cross-functional teams across GSK, this role ensures scientific alignment, portfolio coherence, and development excellence across assets. This is a senior individual contributor position that operates across the full breadth of an Oncology portfolio rather than within a single programme, enabling cross-asset integration and strategic alignment across development activities. The PIL applies a disease-level clinical and scientific lens across the portfolio, integrating disease biology, biomarker strategy, and emerging clinical approaches to define what is scientifically feasible and inform development pathways across programmes. This includes bringing clinical context to novel biomarker strategies and trial designs, particularly for early-stage and mechanistically novel assets and across programmes with similar indications. The position is open to candidates from either a medical or non-medical background based on the expertise required to be successful operating at the intersection of oncology disease strategy, clinical development, and portfolio leadership.

Requirements

• Bachelor’s / Master’s / Advanced degree in a scientific or medical discipline.
• Candidates may come from a medical or scientific background; oncology drug development expertise with defined experience is expected.
• Experience in oncology drug development within pharmaceutical or biotechnology environments, including involvement across multiple programs or assets.
• Experience of clinical development processes, regulatory pathways, and oncology therapeutic landscapes.
• Experience in operating structured matrix organizations and demonstrate decision-making and stakeholder engagement at senior organizational levels.

Nice To Haves

• Experience as a Clinical Development Lead, Medical Director, Clinical Scientist Program Lead, or equivalent program leadership role in oncology.
• Expertise in biomarker development, precision medicine strategies, or combination therapy approaches.
• Experience engaging with external scientific experts, advisory groups, and Health Authorities.
• Demonstrated ability to influence senior stakeholders and shape strategic portfolio discussions.
• Familiarity with clinical trial innovation methods, including AI/ML applications, adaptive trial designs, or real-world evidence integration.

Responsibilities

• Provide senior scientific partnership to CDLs, particularly in areas such as disease biology, biomarker strategy, and novel treatment combinations development.
• Ensure consistent cross-programme ways of working to improve development efficiency and execution.
• Drive cross-programme portfolio working groups and ensure business level alignment
• Drive and support clinical trial innovation based on evolving oncology treatment landscape, government regulations, basic/translational science, and emerging technologies (such as AI-enabled tools).
• Strengthen the scientific and strategic positioning of a pan-asset portfolio across multiple clinical and pre-clinical assets.
• Drive initiatives that advance data and technology strategies supporting development decision-making.
• Shape engagement with external experts and governance bodies including advisory boards where relevant.
• Shape the advancement of multiple development programs within the oncology portfolio by providing scientific insights across assets, ensuring that agreed disease strategy is implemented consistently across programs.
• Prepare detailed strategic analyses and portfolio recommendations on behalf of the Disease Area Vice President, enabling effective decision-making at senior leadership and governance levels.
• Ensure alignment and coordination across Clinical Matrix Teams (CMTs) and relevant cross-functional stakeholders in Research & Development (R&D), Global Medical Affairs (GMA) and Global Product Strategy (GPS).
• Drive disease-level strategic discussions and portfolio planning, bringing a pan-asset perspective to governance discussions and portfolio prioritization.
• Serve as a subject matter expert supporting global health authority interactions, regulatory submissions and key development milestones across multiple assets.
• Serve as a scientific thought partner to CDLs across multiple asset programs, shaping key aspects of clinical development strategy for a given tumour types, including: disease biology and translational science biomarker and precision medicine approaches combination strategies emerging clinical development opportunities
• Establish and champion consistent ways of working across programs to improve efficiency and development quality.
• Drive innovation in clinical development approaches for a given disease area, including trial design, novel endpoints, and emerging technologies such as AI-enabled analytics where appropriate.
• Maintain a deep understanding of the evolving tumour disease landscape, standards of care, and emerging science.
• Shape engagement with external experts through advisory boards.
• Synthesise portfolio-level external insights to inform and strengthen development strategy across multiple programs.
• Drive initiatives that strengthen the application of data, technology, and analytics in clinical development decision-making for a given tumour type.
• Champion innovative approaches to clinical trials and portfolio insights, ensuring the tumour portfolio remains at the forefront of emerging capabilities.

Benefits

• GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
• We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
• Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at [email protected] where you can also request a call.
• Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree