Senior Director, Market Access Strategy

Amylyx Pharmaceuticals • Cambridge, MA

1d • Remote

About The Position

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity We are seeking a Senior Director, Market Access Strategy to support a new product launch. This leader will own the creation of the payer value proposition, lead pricing strategy for launch, and prepare effective communications across payer, distribution channel, field access, and patient support teams. As a key member of the Market Access leadership team, you will work cross functionally to drive strategies for all market access functions, oversee a post-launch marketing and pricing operations team, and effectively manage any vendors that support these initiatives.

Requirements

• Bachelor’s degree required
• 12+ years of experience in pharmaceutical market access, pricing, reimbursement strategy, and payer marketing
• Prior launch experience in US market
• Deep expertise in the U.S. payer, reimbursement, coverage, and coding landscape for specialty products under the pharmacy benefit
• Proven experience developing payer value propositions and payer‑facing materials
• Strong analytical skills using market access data sources (e.g., HUB, specialty pharmacy, and claims data)
• People leadership experience, including hiring, coaching, and developing teams
• Demonstrated experience with pricing strategy, contract modeling, and gross‑to‑net management
• Strong vendor management and contracting experience across agencies, consultants, analytics partners, and pricing operations vendors

Responsibilities

• Shape and lead the payer value story for Amylyx’s first launch product, translating clinical, economic, and real‑world evidence into a differentiated, evidence‑based value proposition that supports optimal access and reimbursement.
• Drive payer marketing and launch execution in close partnership with Medical Affairs, including development of PIE content, AMCP dossiers, and comprehensive launch education materials.
• Partner with Medical and Access leadership to define payer evidence requirements, identify data gaps, and execute strategies to address unmet needs across pre‑ and post‑launch phases.
• Develop and deploy access tools and communications that enable field access teams, patient support programs, and pharmacy partners to execute effectively and consistently.
• Establish a cross‑functional performance feedback loop across payer, field access, pharmacy, and services teams to rapidly identify access barriers and drive issue resolution.
• Build and oversee post‑launch pricing operations, including list price governance, price change management, pricing committee leadership, and close collaboration with Finance on gross‑to‑net management.
• Lead agencies and vendors, monitor payer and policy dynamics, and represent market access strategies including performance, risks, and opportunities—to internal stakeholders and senior leadership.

What This Job Offers

• Job Type: Full-time
• Career Level: Director