Senior Director, HR Operations

Cabaletta Bio Inc.•Philadelphia, PA

7d•Onsite

About The Position

The Senior Director, HR Operations is a strategic and execution‑focused leader responsible for building and scaling a modern, data‑driven HR infrastructure that enables organizational growth, operational excellence, and an exceptional employee experience. Reporting into the CHRO, this role will lead HR technology, global HR operations, compliance, and people analytics, while also serving as a trusted HR Business Partner for a few key business leaders. The role will partner closely with Finance, Legal, and Business leadership to ensure that HR processes, systems, and insights are efficient, scalable, compliant, and aligned to business priorities, particularly in a dynamic, high‑growth environment. The ideal candidate brings a track record of implementing HR systems, automating operations, leveraging analytics for decision‑making, and partnering with executive leadership, along with experience supporting compensation and benefits programs.

Requirements

Bachelor’s degree required; advanced degree (MHRM, MBA, or related) preferred.
15+ years of progressive HR experience, with focus in HR Operations and people analytics
Demonstrated success leading HR technology implementations and transformations
Experience building or scaling HR infrastructure in high‑growth or dynamic environments (biotech, tech, or similar industries preferred)
Strong working knowledge of global HR compliance and employment practices
Experience supporting compensation processes and benefits programs
Track record of partnering with executive leaders and influencing decisions
High level of judgment, adaptability, and resilience in fast‑paced environments
Exceptional communication and stakeholder management skills
Ability to operate effectively in a fast-paced, collaborative, and evolving environment.

Responsibilities

Lead and optimize global HR operations across employee lifecycle processes (hire‑to‑retire), ensuring efficiency, scalability, and strong employee experience
Design and implement standardized workflows, policies, and service delivery models to support growth, while driving continuous improvement, reducing manual processes and increasing operational effectiveness
Own the implementation and optimization of HR systems (HCM, ATS, performance management tools, etc.), including integration and migration from a legacy PEO
Partner with IT and business stakeholders to deliver scalable, user‑centric solutions
Drive adoption of new systems, processes, and programs with high engagement and minimal disruption
Leverage AI, automation, and digital tools to enhance HR service delivery, insights, and employee engagement
Establish and track metrics such as time‑to‑fill, productivity, retention, and diversity goals, providing real‑time visibility into headcount, attrition, engagement, performance, and hiring metrics
Translate data into actionable insights that inform workforce planning, organizational design, and business decisions
Support Compensation planning cycles (merit, bonus, equity) and Market benchmarking and job architecture
Contribute to design and administration of competitive, scalable benefits programs
Serve as an HR partner to designated business leaders, providing guidance on organizational design, workforce planning, talent and performance management
Support leaders with data‑driven insights and pragmatic solutions that balance speed, quality, and culture
Act as a trusted advisor during periods of growth, transformation, or change, and lead operational readiness for rapid growth and organizational changes
Support culture evolution through scalable HR practices that reinforce company values and performance expectations