Senior Director Health Economics Outcomes Research

GRIFOLS, S.A.•NC-RTP, CA

4d•Onsite

About The Position

Grifols is seeking a visionary and scientifically grounded leader for an industry-leading Global HEOR/RWE team. The successful candidate will partner with cross-functional stakeholders to ensure HEOR/RWE plans and deliverables are scientifically rigorous, decision-relevant, and ready to support clinical studies, payer/HTA engagement, pricing, and reimbursement. With responsibility across a diverse therapeutic portfolio and modalities — including plasma-derived products and recombinant proteins — this role offers a rare opportunity to build future-ready Global HEOR/RWE capabilities, influence portfolio strategy, and lead a dynamic team to translate deep scientific insight into medicines that meaningfully improve patients’ lives.

Requirements

MD, MD/PhD, PhD, PharmD, or equivalent advanced scientific/medical degree
Typically 15+ years of experience in HEOR/RWE within pharma, biotech, or medical devices
Deep knowledge of outcomes research and RWE methodologies (study design, statistics, data sources, and implementation)
Proven experience managing vendors, budgets, and building productive partnerships with internal stakeholders and external experts/KOLs
Excellent communication skills, with the ability to translate complex analyses into clear recommendations for senior stakeholders
Demonstrated leadership in matrixed environments, including the ability to direct work across functions to deliver shared objectives
Experience across multiple therapeutic areas; experience in Neurology, Immunology, Hematology, Coagulation, and/or Critical Care is preferred
Experience across multiple therapeutic areas and development modalities is strongly preferred
Credible, team-oriented HEOR/RWE leader with executive presence and a strategic mindset
Collaborative, inclusive leader who inspires teams and encourages innovation
Comfortable navigating complexity, ambiguity, and change
Strong communicator with the ability to influence at senior and executive levels
Hands-on, pragmatic, and outcomes-driven, aligned with Grifols’ culture and values

Nice To Haves

Experience in Neurology, Immunology, Hematology, Coagulation, and/or Critical Care is preferred
Experience across multiple therapeutic areas and development modalities is strongly preferred

Responsibilities

Define and own the global HEOR/RWE vision, strategy, and multi-year evidence generation roadmap, ensuring alignment with pipeline, launch, and lifecycle priorities and integration of RWE into value demonstration, HTA engagement, and pricing and reimbursement decision-making.
Provide senior scientific leadership to cross-functional teams and executive management, serving as a trusted advisor on program risk, opportunity, and strategic trade-offs.
Define the enterprise strategy for the use of RWE in regulatory, payer, and HTA contexts, serving as the senior HEOR/RWE partner to Regulatory Affairs and global health authorities.
Lead integrated evidence planning with cross-functional stakeholders to align research questions, endpoints, and study designs with payer/HTA requirements and value hypotheses.
Establish and govern Global HEOR/RWE standards, processes, and quality frameworks to ensure scientific rigor, consistency, compliance, and decision-grade evidence across deliverables.
Lead the design, execution, and interpretation of HEOR/RWE studies (e.g., comparative effectiveness, burden of illness, treatment patterns, PRO/COA, registries, claims/EHR analyses, and economic models), ensuring fit-for-purpose methods and clear decision recommendations.
Ensure evidence is translated into access-enabling deliverables (e.g., global value dossier/AMCP dossier content and support for HTA submissions), aligned to stakeholder needs across priority markets.
Oversee the end-to-end HEOR/RWE portfolio (book of work), including prioritization, resourcing, budgets, timelines, performance metrics, and proactive risk management.
Lead the publication and dissemination strategy for HEOR/RWE projects to strengthen scientific credibility and visibility in priority disease areas.
Monitor evolving methodologies and policy trends across payers, HTA bodies, and RWE to inform standards, training, and evidence strategy updates.
Lead and develop a globally-distributed HEOR/RWE team (health economists, outcomes researchers, epidemiologists, statisticians/analysts, and scientific communications partners), including hiring, coaching, performance management, and succession planning.
Build and scale operating capabilities (data strategy, analytics, vendor ecosystem, tools, and training) to support pipeline growth and lifecycle evidence needs.
Ensure excellence in scientific quality, documentation, and compliance (e.g., protocol/SAP governance, data privacy, vendor oversight, and audit readiness) across HEOR/RWE activities.
Drive continuous improvement of HEOR/RWE operations, including ways of working, tools, and training to increase speed and quality of delivery.
Partner with key stakeholders (Clinical Development, Regulatory, Biostatistics, Medical Affairs, Pharmacovigilance, Commercial/Market Access, Legal, Finance, and Global Program Teams) to align evidence plans with development and access priorities.
Foster a collaborative, matrix-based culture that promotes transparency, scientific rigor, and shared ownership of outcomes.
Represent HEOR/RWE in internal governance bodies and executive forums, communicating evidence strategy, insights, and implications for access and value positioning.
Develop and maintain strategic external relationships (payers, HTA bodies, KOLs, scientific societies, and patient advocacy groups) to inform evidence standards and enhance value communication.