Senior Director, Head of Structural Biology

Revolution Medicines•Redwood City, CA

8d•$244,000 - $305,000•Onsite

About The Position

Revolution Medicines is seeking a Senior Director, Head of Structural Biology, to lead the scientific strategy, team development, and operations of its Structural Biology group. The group integrates X-ray crystallography, NMR, and cryo-EM to advance oncology drug discovery through the company’s tri-complex molecular glue platform. The role partners closely with medicinal and computational chemistry, project teams, and biologists to guide compound design and optimization, investigate structure-function relationships, and understand mechanisms of action. The successful leader will define the next stage of structural biology capabilities by identifying technologies, talent, and external partnerships that can improve discovery decisions and extend the reach of the platform. The role will shape understanding and design of compound-induced protein interactions, translating molecular recognition, cooperativity, and conformational dynamics into improved molecules and new therapeutic opportunities. It combines scientific judgment with strategic leadership, cross-functional influence, and accountability for group performance and resources. The position is based onsite at Revolution Medicines’ headquarters in Redwood City, California. The base pay range for this full-time position is $244,000–$305,000 USD, subject to location and individual qualifications. The company also describes competitive cash compensation, equity awards, benefits, and learning and development opportunities.

Requirements

PhD in structural biology, biophysics, biochemistry, or a related discipline.
12+ years of biotechnology or pharmaceutical industry experience, with a demonstrated record of scientific and people leadership.
Proven ability to lead a structural biology group, develop scientific leaders, and translate research strategy into priorities, resource plans, and measurable outcomes across multiple discovery programs.
Deep expertise in at least one of X-ray crystallography, NMR, or cryo-EM, and sufficient breadth across all three to guide specialists, critically evaluate data, and develop integrated experimental strategies.
Strong track record applying structural biology to small-molecule drug discovery in close partnership with medicinal chemistry, including translating structural findings into compound design and optimization decisions.
Expertise in protein-ligand and protein-protein interactions, complex assembly, and structure-function analysis, with ability to integrate structural, biophysical, biochemical, and cellular evidence into testable mechanistic models.
Experience integrating structural methods with computational modeling, molecular simulation, or complementary biophysical approaches to explain molecular recognition and dynamics.
Strategic judgment in solving complex scientific problems, anticipating capability needs, and managing competing priorities, budgets, and internal and external resources.
Excellent communication and cross-functional leadership skills, including influencing senior stakeholders, building alignment, and communicating scientific uncertainty and tradeoffs.
Ability to develop talent, welcome diverse perspectives, maintain high scientific and ethical standards, and sustain effective collaboration in a growing research organization.
Experience establishing or expanding structural biology capabilities and external collaborations in a growing biotechnology organization.

Nice To Haves

Experience with molecular glues or other small molecules that induce or stabilize protein interactions, including familiarity with ternary-complex characterization, cooperativity, and mechanisms of selectivity.

Responsibilities

Set and execute the Structural Biology strategy with research leadership, aligning immediate program needs and long-term capability development with portfolio and platform priorities.
Lead and develop scientists across crystallography, NMR, and cryo-EM by setting expectations, coaching, and supporting career growth.
Partner with medicinal, computational, and digital discovery scientists to integrate experimental structures, predictive models, and molecular simulations into hypotheses that guide molecular design, structure-activity relationship interpretation, compound optimization, and validation, while assessing confidence and risk.
Work with project teams and Structural Biology colleagues to define structure-function questions and design integrated studies with biochemistry, biophysics, and cellular biology to test mechanisms and inform program decisions.
Lead investigations of the tri-complex glue platform, including protein-partner recognition, ternary-complex architecture, cooperativity, conformational dynamics, and selectivity, and identify principles that inform new targets and discovery approaches.
Direct the complementary use of crystallography, NMR, and cryo-EM, choosing suitable methods for each scientific question and guiding solutions to challenging protein and complex characterization problems.
Prioritize and allocate group resources, balancing program delivery with exploratory platform research.
Model scientific rigor, integrity, and commitment to patients, and foster an inclusive culture of collaboration, constructive debate, accountability, and continuous learning.