Senior Director, Enterprise Applications

Stoke Therapeutics•Bedford, MA

2h•$260,000 - $305,000•Hybrid

About The Position

Stoke Therapeutics is seeking a Senior Director, Enterprise Applications to own its General and Administrative (G&A) application portfolio and the SOX IT general controls for those systems. The portfolio includes NetSuite ERP, ADP HRIS and payroll, learning management, financial planning, procurement, expense, contract lifecycle management and corporate tools. The immediate priority is to lead the NetSuite extension for commercial launch, covering revenue, inventory, order-to-cash and CMO/3PL integration, alongside an implementation partner through 2027. The role is the named IT partner to Finance, HR, Legal, Compliance, Procurement and Internal Audit; a member of the IT leadership team; and reports to the VP, Enterprise Technology & Architecture. The position leads the Enterprise Applications team, initially including a Business Systems Analyst, Financial Systems, with additional hires planned as the ERP program and commercial scope grow. It also manages implementation partners, contractors and managed service providers. The role is a hybrid position currently based in Bedford, Massachusetts, and will later be based in Waltham, Massachusetts. Approximately 5% travel is required. The anticipated salary range is $260,000–$305,000, with an annual bonus and equity participation. Stoke's benefits include medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401(k) plan with company match; unlimited vacation time; tuition assistance; and participation in the Employee Stock Purchase Program.

Requirements

Bachelor's degree in business, accounting, information systems or a related field.
12 or more years of IT experience in biotech or life sciences, including 5 or more years leading enterprise applications, business systems or a broader IT function.
Experience at a public company operating under SOX.
Experience leading an ERP implementation or significant extension as the accountable IT leader working through an implementation partner.
Working familiarity with NetSuite and ADP.
Demonstrated functional leadership, including hiring and developing staff, setting priorities, managing budgets, implementers and managed service providers, and partnering with executives in Finance, HR and Legal.
Deep working knowledge of SOX IT general controls and application controls, with experience working directly with internal and external auditors.
Experience with HRIS/payroll, learning management, procurement, expense and FP&A platforms and the business processes they support.
Strong business process and requirements skills, including the ability to challenge and partner effectively with Finance leadership.
Vendor, implementation partner and program management experience across projects ranging from small enhancements to enterprise-scale implementations.
Working knowledge of SaaS integration patterns and cloud concepts, and a solid grounding in cybersecurity and data privacy principles as they apply to finance and HR data.
Familiarity with 21 CFR Part 11 and computer systems validation as they apply to ERP and supply chain functions.
Excellent written and verbal communication skills; comfortable presenting to and training groups.
Curious, collaborative and adaptable, with a seek-to-understand approach to business partners and the ability to work autonomously and take on new responsibilities as the company grows.

Nice To Haves

Advanced degree, CPA or PMP.
Experience adding order-to-cash, inventory and 3PL/distribution capabilities to an ERP for a product launch.
Experience building and leading a G&A applications team in a biotech company that has moved from clinical-stage to commercial.
Experience supporting a company's transition from clinical-stage to commercial, including gross-to-net, revenue recognition and serialization/DSCSA touchpoints.
Experience with integration platforms and finance data warehousing.
Experience introducing enterprise AI tools with policy, training and access governance.

Responsibilities

Lead the NetSuite extension program for commercial launch, including scope, design, build, data migration, testing, cutover and hypercare.
Coordinate NetSuite integration with CMO/CDMO, 3PL and distribution partners, and any supply-planning solution layered on NetSuite; manage the implementation partner.
Own the roadmap and day-to-day operations for NetSuite, ADP and G&A applications, including small enhancements and enterprise-scale programs.
Set HRIS platform direction alongside the ERP program in partnership with HR.
Own the learning management system in partnership with HR, Legal, Compliance and Marketing/L&D, coordinating with Clinical & Regulatory Systems where it delivers GxP training under validated controls.
Serve as IT partner to Finance, HR, Legal, Compliance, Procurement and Internal Audit; understand their strategic objectives and operational challenges, translate business needs into solutions, and lead process and system design decisions.
Identify opportunities to streamline G&A processes and extend system capabilities.
Own SOX IT general controls and application controls for in-scope systems, including access reviews, change control, audit evidence and remediation with Internal Audit and external auditors.
Lead the Enterprise Applications team and manage implementers, contractors and MSP resources.
Oversee the NetSuite managed service provider, including service levels, release management, escalations and post-go-live optimization.
Bring AI capabilities embedded in NetSuite, ADP and G&A platforms through the AI Steering Committee's governance process and into use; contribute to the enterprise AI program.
Partner with Clinical & Regulatory Systems on GxP-impacted G&A application functions, including drug product inventory, lot traceability and distribution, to meet 21 CFR Part 11 and validation requirements alongside SOX controls.
Drive adoption through application demonstrations, end-user training and change management for new capabilities and process changes.
Keep enterprise applications documentation current and contribute to IT SOPs, policies and procedures.
Establish integration patterns and master data governance for finance, HR and procurement data in line with enterprise architecture standards.
Lead month-end and quarter-end system support, release management and platform upgrades.
Manage vendor contracts, licensing and the Enterprise Applications budget; report program status through the IT PMO.
Contribute to IT strategy and standards as a member of the IT leadership team.