Senior Director, Delivery

Sail Biomedicines•Cambridge, MA

18h

About The Position

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. This role will lead the strategy and execution of delivery innovation from early discovery through preclinical development, enabling robust, scalable, and translatable delivery solutions across Sail’s pipeline. This individual will bring deep technical expertise in lipid nanoparticle design and formulation, as well as demonstrated experience in targeted delivery approaches, including ligand-mediated targeting, bioconjugation, and receptor-specific delivery strategies. They will play a central role in shaping Sail’s delivery capabilities, expanding tissue and cell-type reach, and unlocking new therapeutic applications. The Sr Director will operate at the intersection of Platform, Programs and Technical Development, working cross-functionally to translate delivery innovations into high-impact programs. They will lead a team of scientists and serve as a key thought partner to senior leadership on delivery strategy, platform investments, portfolio prioritization, and technical risk. This role is accountable for the foundational and Delivery capability at Sail, ensuring that targeted nanoparticle systems are not only innovative but also translatable and scalable, enabling continued pipeline progression to development candidates.

Requirements

PhD or MD in drug delivery, chemical engineering, materials science, pharmaceutical sciences, or a related discipline with 12+ years of relevant industry experience.
Deep expertise in lipid nanoparticle (LNP) systems, including formulation development, lipid chemistry, and in vitro/in vivo evaluation of delivery performance.
Demonstrated experience in targeted delivery approaches, including ligand conjugation, receptor-mediated targeting, and nanoparticle surface engineering.
Strong understanding of nucleic acid delivery challenges, including biodistribution, cellular uptake, endosomal escape, and immunogenicity.
Experience advancing delivery technologies toward IND-enabling studies or clinical translation, with an appreciation for scalability, manufacturability, and regulatory considerations.
Proven track record of advancing delivery technologies from discovery through preclinical development.
Experience building and leading multidisciplinary scientific teams in a fast-paced biotech environment.
Ability to operate strategically while remaining deeply connected to scientific detail and execution.
Strong cross-functional leadership skills, with experience working across chemistry, biology, process development, and translational teams.
Excellent communication skills, with the ability to influence senior stakeholders and clearly articulate complex technical concepts.

Responsibilities

Lead and grow Sail’s Delivery team, advancing lipid nanoparticle (LNP) and targeted delivery technologies.
Drive innovation in targeted nanoparticles, including design, formulation, ligand selection and conjugation, receptor-mediated uptake, and cytosolic delivery.
Define and execute delivery strategy across tissues and disease areas, guiding nanoparticle engineering for precise targeting and biodistribution.
Develop and apply high-throughput screening approaches to evaluate delivery performance, including biodistribution, cellular uptake, and functional expression.
Partner with Program teams to advance multiple development candidates, improving efficiency, specificity, and translatability.
Partner with Technical Development to ensure scalable, robust processes supporting progression to clinic.
Lead cross-functional delivery efforts to advance programs from concept through candidate nomination.
Collaborate with ligand design and program teams to align delivery strategies with disease biology and therapeutic goals.
Identify and mitigate key delivery risks to enable program success.
Drive integrated planning across delivery activities, aligning timelines, milestones, and resources.
Manage external collaborations, including CROs and technology partners.
Advise senior leadership on delivery strategy, portfolio prioritization, and execution risks.