Senior Data Scientist, Predictive Immune Biomarkers

Merck•Cambridge, MA

22h•$144,800 - $227,900•Onsite

About The Position

The Precision Genetics group within the Data, AI and Genome Sciences Department is seeking a Senior Scientist to join our Computational Precision Immunology team in Cambridge, MA. We are looking for a skilled data scientist with extensive experience to develop predictive biomarkers in immunology based on multi-modal and multi-scale data analyses.

Requirements

Ph.D. in Computational Biology or a related field.
A proven track record in multi-omics analysis.
Hands-on experience with building, fine-tuning, benchmarking foundation models, preferably for patient stratification related downstream tasks.
Fundamental understanding of AI/ML methods, multi-omics data analysis, and omics integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).
Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.
Experience with high-performance computing (HPC) systems and AWS Cloud Services (e.g., IAM, S3 buckets).
A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.
Excellent written and verbal communication skills.

Nice To Haves

Good understanding of autoimmune disease biology.
Experience in processing and analyzing real-world data.
Familiarity with spatial transcriptomics analysis.
Knowledge of statistical and population genetics principles.

Responsibilities

Build, fine-tune, troubleshoot, and benchmark foundation models for predictive immune biomarker discovery.
Perform quality control (QC) and analysis of different molecular data types including bulk and single-cell RNA-seq (e.g., Limma, Seurat, scanpy), spatial transcriptomics (e.g., CosMx, 10x Visium), and proteomics (e.g., OLINK, mass spectrometry-based approaches).
Integrate multi-omics datasets, including gene/protein expression, spatial transcriptomics, and genotype data.
Prepare detailed documentation of analysis methods and results in a timely manner.