Scientist, Immune Engineering

AstraZeneca • Waltham, MA

1d • Hybrid

About The Position

We are seeking an early-career Scientist to join the Cellular Resilience team to contribute to groundbreaking, early discovery research at the intersection of gene delivery and cell therapy. The successful candidate will leverage their expertise in Immune cell engineering, functional assay development, and synthetic/molecular biology to develop the next generation of cellular therapies.

Requirements

• BS/MS with 5+ years or PhD with 0+ years of post-graduate experience in a relevant field including (but not limited to) molecular biology, synthetic biology, Immunology, Biological/Chemical/Biomedical engineering
• Hands-on experience in the culture and engineering of established cell lines and primary human immune cells by viral and non-viral techniques such as lentivirus, AAV, LNP, electroporation
• Hands-on experience with the execution and data analysis of immune functional assays including in vitro cytotoxicity, co-cultures, proliferation, and cytokine measurement
• Proactive, highly self-motivated, and thrives in a workplace where goals may shift

Nice To Haves

• Experience with multi-color flow cytometry experiment design, acquisition, and analysis
• Experience with gene editing technologies (i.e. CRISPR, TALE, Zinc Finger) and evaluating gene editing outcomes (i.e. Flow cytometry, qPCR, sanger sequence, NGS)

Responsibilities

• Engineering cell lines and primary immune cells by viral and non-viral techniques
• In-vitro cellular assay development with an emphasis on high-throughput readouts such as multicolor flow cytometry, plate reader, ELISA/MSD, qPCR
• Analyze and interpret complex experimental data, present findings to both internal and external stakeholders

Benefits

• Competitive remuneration
• Market driven base salary
• Bonus
• Long-term incentive
• Generous paid time off program
• Comprehensive benefits package
• Eligibility for various incentives
• Opportunity to receive short-term incentive bonuses
• Equity-based awards for salaried roles
• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health coverage
• Dental coverage
• Vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level