Senior Computational Researcher

St. Jude Children's Research Hospital • Memphis, TN

2d • $78,000 - $139,360

About The Position

The Senior Computational Researcher will perform analyses using existing, modified, or newly developed tools/methods. Set up tools and troubleshoot analyses using new or modified computational research techniques. The Lead Discovery Informatics (LDI) Center in the Department of Chemical Biology and Therapeutics (CBT), led by Dr. Anang Shelat , and the Laboratory of Dr. Christoph Gorgulla in the Department of Structural Biology, are seeking a highly motivated computational chemist interested in applying state-of-the-art techniques in computer-aided drug design to discover novel small molecule modulators of targets relevant to pediatric disease. The applicant is expected to work alongside domain experts in the biology of pediatric disease, chemists, and pharmacologists, as well as the various institutional shared resources devoted to translational science, in a collaborative project team environment. The applicant must have a strong background in computational chemistry, including molecular dynamics simulations, virtual screening, quantitative structure activity relationship modeling, and chemical informatics. The applicant must also be comfortable using high performance computing resources; and developing, maintaining, and mining chemical and biological databases. Experience with designing proximity-based small molecule modulators, such as PROTACs and molecular glues, is welcome. Proficiency in scientific computing languages, such as R and python, and open-source programing tools such as Knime, RDKit, and ChemProp, is a plus. LDI is a world-class collaborative research center with expertise in chemical informatics, molecular simulation, computer-aided molecular design, and chemically aware machine learning. Our mission is to enable a deeper interrogation of biology through the integration of chemistry, computation, and data science. The Gorgulla lab has pioneered the development of next generation methods for computational biology and ligand/drug discovery based on ultra-large virtual screenings, artificial intelligence, quantum chemistry, and quantum computing. Individuals with bold vision and who demonstrate excellence in research at the interface of chemistry, biology, and medicine are encouraged to join our team.

Requirements

• Bachelors in bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field required.
• Bachelor's degree and 4+ years of relevant experience.
• Experience leading and supporting computational research.
• Some experience in research support activities.
• Proven performance in earlier role/ comparable role.

Nice To Haves

• Master's degree preferred.
• Experience Exception: Master's degree and 1+ years of relevant experience.
• Experience with designing proximity-based small molecule modulators, such as PROTACs and molecular glues, is welcome.
• Proficiency in scientific computing languages, such as R and python, and open-source programing tools such as Knime, RDKit, and ChemProp, is a plus.
• The applicant must have a strong background in computational chemistry, including molecular dynamics simulations, virtual screening, quantitative structure activity relationship modeling, and chemical informatics.
• The applicant must also be comfortable using high performance computing resources; and developing, maintaining, and mining chemical and biological databases.

Responsibilities

• Perform analyses using existing, modified, or newly developed tools/methods.
• Set up tools, and troubleshoot analyses using new or modified computational research techniques.
• Identify data pertinent to the analysis problem; process, organize, and summarize data; report results.
• Assist in the drafting and editing of manuscripts.
• Provide guidance to entry-level employees.
• Perform other duties as assigned to meet the goals and objectives of the department and institution.
• Maintains regular and predictable attendance.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level